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- W762378328 abstract "A potential dual inhibitor(4) for exogenous absorption and endogenic synthesis of cholesterol was designed based on the conjugation of the β-lactam pharmacophore of ezetimibe and the δ-lactone pharmacophore of statins. The merger of ezetimibe and statin 4 was synthesized from p-hydroxybenzaldehyde through a ten-step route. 1H NMR analysis showed existence of four pairs of enantiomers(5.7:5.7:1:1, molar ratio). And compound 4 was found to lower total glucose(TG) level in rat serum via a high-cholesterol and high-fat feeding experiment." @default.
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- W762378328 date "2011-01-01" @default.
- W762378328 modified "2023-09-23" @default.
- W762378328 title "Merger of Ezetimibe and Statin: a Potential Dual Inhibitor" @default.
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