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• W76242506 abstract "Since Xylazine (XYLA) is commonly used in equine practice, and because its use can result in adverse effects even with combination with analgesics, a reliable and safe pharmacological antagonist would be useful. The aim of this study is to compare the efficacy of Tolazoline (TOLA) and Atipamezole (ATIP) for reversal of XYLA plus Butorphanol (BUTO) effects in donkeys. Three donkeys were used. Each donkey was used in 3 occasions, at 2 weeks intervals. First treatment (XYLA+BUTO, as 1.1 mg/kg and 0.04 mg/kg, respectively), second treatment (XYLA+BUTO followed by TOLA, as 4 mg/kg) and third treatment (XYLA+BUTO followed by ATIP, as 0.1 mg/kg). TOLA and ATIP were given i.v. 15 minutes (min) after i.v. administration of XYLA+BUTO. Onset, duration and reverse of sedation, analgesia and ataxia as well as changes in clinical parameters were recorded. Blood samples were collected for hematobiochemical analysis. Descriptive statistical analysis was performed. The resultant sedation, analgesia and ataxia following XYLA+BUTO and the changes in the clinicohematobiochemical parameters were restored insignificantly by TOLA and ATIP. It is concluded that either TOLA or ATIP provide a suitable antagonistic action for the effects of XYLA-BUTO combination in donkeys. TOLA proved specific antagonist for such combination." @default.
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• W76242506 date "2011-01-01" @default.
• W76242506 modified "2023-09-27" @default.
• W76242506 title "ANTAGONISM OF XYLAZINE - BUTORPHANOL COMBINATION IN DONKEYS USING TOLAZOLINE / ATIPAMEZOLE" @default.
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