FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W762452958> ?p ?o ?g. }

• W762452958 endingPage "938" @default.
• W762452958 startingPage "929" @default.
• W762452958 abstract "Tanshinone IIA (TIIA), a diterpene quinone from the medicinal plant Salvia miltiorrhiza Bunge (Lamiaceae) was shown to possess apoptotic and TRAIL-sensitizing effects. Still, the molecular mechanisms whereby TIIA induces apoptosis remain largely unknown. The role of survivin, an inhibitor of apoptosis protein, in TIIA-induced apoptosis has never been addressed before and hence was the primary goal of this study. In this study, we explored the anticancer effect of TIIA in TOV-21G, SKOV3, and OVCAR3 ovarian carcinoma cells. Cytotoxicity was determined by MTS assay. Real-time RT-PCR and Western blotting were used to assess the mRNA and protein expression of related signaling proteins. Our results illustrated that TIIA's cytotoxic effect was caused by apoptosis with the involvement of caspases activity. Moreover, TIIA downregulated survivin in a concentration-dependent manner without affecting the expression of Bcl-2, Bcl-xL, and Bax. TIIA-induced survivin downregulation is regulated by both transcriptional processes and proteasomal degradation. Using TOV-21G cells as our cellular model, we demonstrated that TIIA-induced survivin downregulation requires p38 MAPK activation. Importantly, genetic overexpression of survivin rendered cells more resistant to TIIA, indicating an essential role of survivin downregulation in TIIA-induced apoptosis. This TRAIL sensitization effect of TIIA is ascribed to survivin downregulation because the effect was abrogated in cells that overexpressed survivin. Our findings provide new insights into the action modes of TIIA-mediated anticancer effects and further implicate a rational design for cancer therapeutic regimens by combining TIIA-sensitized TRAIL via downregulating survivin to elicit ovarian cancer cell death." @default.
• W762452958 created "2016-06-24" @default.
• W762452958 creator A5015997306 @default.
• W762452958 creator A5040743699 @default.
• W762452958 creator A5044119541 @default.
• W762452958 creator A5049858306 @default.
• W762452958 date "2015-09-01" @default.
• W762452958 modified "2023-09-25" @default.
• W762452958 title "Tanshinone IIA enhances the effects of TRAIL by downregulating survivin in human ovarian carcinoma cells" @default.
• W762452958 cites W1863167619 @default.
• W762452958 cites W1971593888 @default.
• W762452958 cites W1982383186 @default.
• W762452958 cites W1982791974 @default.
• W762452958 cites W1984722635 @default.
• W762452958 cites W1996312262 @default.
• W762452958 cites W2007718868 @default.
• W762452958 cites W2016580965 @default.
• W762452958 cites W2018247784 @default.
• W762452958 cites W2025043157 @default.
• W762452958 cites W2027730833 @default.
• W762452958 cites W2033406969 @default.
• W762452958 cites W2038465110 @default.
• W762452958 cites W2042633087 @default.
• W762452958 cites W2048962308 @default.
• W762452958 cites W2053992683 @default.
• W762452958 cites W2055137634 @default.
• W762452958 cites W2058910967 @default.
• W762452958 cites W2071209143 @default.
• W762452958 cites W2080304960 @default.
• W762452958 cites W2082738001 @default.
• W762452958 cites W2101907683 @default.
• W762452958 cites W2112849045 @default.
• W762452958 cites W2118540273 @default.
• W762452958 cites W2123113463 @default.
• W762452958 cites W2124367950 @default.
• W762452958 cites W2171139000 @default.
• W762452958 doi "https://doi.org/10.1016/j.phymed.2015.06.012" @default.
• W762452958 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26321742" @default.
• W762452958 hasPublicationYear "2015" @default.
• W762452958 type Work @default.
• W762452958 sameAs 762452958 @default.
• W762452958 citedByCount "17" @default.
• W762452958 countsByYear W7624529582015 @default.
• W762452958 countsByYear W7624529582016 @default.
• W762452958 countsByYear W7624529582017 @default.
• W762452958 countsByYear W7624529582018 @default.
• W762452958 countsByYear W7624529582019 @default.
• W762452958 countsByYear W7624529582020 @default.
• W762452958 countsByYear W7624529582021 @default.
• W762452958 crossrefType "journal-article" @default.
• W762452958 hasAuthorship W762452958A5015997306 @default.
• W762452958 hasAuthorship W762452958A5040743699 @default.
• W762452958 hasAuthorship W762452958A5044119541 @default.
• W762452958 hasAuthorship W762452958A5049858306 @default.
• W762452958 hasConcept C104317684 @default.
• W762452958 hasConcept C127561419 @default.
• W762452958 hasConcept C142724271 @default.
• W762452958 hasConcept C185592680 @default.
• W762452958 hasConcept C188947578 @default.
• W762452958 hasConcept C190283241 @default.
• W762452958 hasConcept C204787440 @default.
• W762452958 hasConcept C2775975398 @default.
• W762452958 hasConcept C2776332195 @default.
• W762452958 hasConcept C2777408456 @default.
• W762452958 hasConcept C31573885 @default.
• W762452958 hasConcept C502942594 @default.
• W762452958 hasConcept C55493867 @default.
• W762452958 hasConcept C71924100 @default.
• W762452958 hasConcept C98274493 @default.
• W762452958 hasConceptScore W762452958C104317684 @default.
• W762452958 hasConceptScore W762452958C127561419 @default.
• W762452958 hasConceptScore W762452958C142724271 @default.
• W762452958 hasConceptScore W762452958C185592680 @default.
• W762452958 hasConceptScore W762452958C188947578 @default.
• W762452958 hasConceptScore W762452958C190283241 @default.
• W762452958 hasConceptScore W762452958C204787440 @default.
• W762452958 hasConceptScore W762452958C2775975398 @default.
• W762452958 hasConceptScore W762452958C2776332195 @default.
• W762452958 hasConceptScore W762452958C2777408456 @default.
• W762452958 hasConceptScore W762452958C31573885 @default.
• W762452958 hasConceptScore W762452958C502942594 @default.
• W762452958 hasConceptScore W762452958C55493867 @default.
• W762452958 hasConceptScore W762452958C71924100 @default.
• W762452958 hasConceptScore W762452958C98274493 @default.
• W762452958 hasIssue "10" @default.
• W762452958 hasLocation W7624529581 @default.
• W762452958 hasLocation W7624529582 @default.
• W762452958 hasOpenAccess W762452958 @default.
• W762452958 hasPrimaryLocation W7624529581 @default.
• W762452958 hasRelatedWork W2031056725 @default.
• W762452958 hasRelatedWork W2034752366 @default.
• W762452958 hasRelatedWork W2042500493 @default.
• W762452958 hasRelatedWork W2053541213 @default.
• W762452958 hasRelatedWork W2364023809 @default.
• W762452958 hasRelatedWork W2782592116 @default.
• W762452958 hasRelatedWork W2827491990 @default.
• W762452958 hasRelatedWork W2896214335 @default.
• W762452958 hasRelatedWork W3032383418 @default.

• next