Matches in SemOpenAlex for { <https://semopenalex.org/work/W76252318> ?p ?o ?g. }
- W76252318 endingPage "67" @default.
- W76252318 startingPage "58" @default.
- W76252318 abstract "Polyvinylpyrrolidone (PVP) and poly(ethylene glycol) (PEG) solid dispersions with Felodipine or Hesperetin having up to 20 wt% drug were prepared using solvent evaporation method. Solid dispersions in comparison with their physical mixtures were studied using differential scanning calorimetry (DSC), wide-angle X-ray diffraction (WAXD), scanning electron microscopy (SEM) and hot stage polarizing light microscopy (HSM). PVP formulations with low drug load proved to be amorphous, since no crystalline Felodipine or Hesperetin drugs were detected using DSC and WAXD. Low and fast heating rates were applied for DSC study, to prevent changes in the samples caused during heating. Similarity between results of WAXD and DSC was also found in the case of physical mixtures, where the drug was in the crystalline state. However, though specific tests showed the high sensitivity of the DSC technique, it was difficult to arrive to reliable results for PEG solid dispersions or physical mixtures with low drug content by DSC, even by high heating rates. Crystalline drug could not be detected by DSC, leading to erroneous conclusions about the physical state of the drug, in contrast to WAXD. On the other hand, HSM proved the presence of small drug particles in the solid dispersions with PEG and the dissolution of the drug in the melt of PEG on heating. In such systems, in which a polymer with low melting point is used as drug carrier, DSC is inappropriate technique and must be used always in combination with HSM. The coupling of WAXD with thermal analysis, allowed complete physicochemical characterization and better understanding which is essential for a first prediction of dissolution characteristics of such formulations." @default.
- W76252318 created "2016-06-24" @default.
- W76252318 creator A5015819023 @default.
- W76252318 creator A5019216041 @default.
- W76252318 creator A5032405012 @default.
- W76252318 creator A5044734486 @default.
- W76252318 creator A5057836455 @default.
- W76252318 creator A5059143159 @default.
- W76252318 creator A5073844357 @default.
- W76252318 date "2005-12-01" @default.
- W76252318 modified "2023-10-07" @default.
- W76252318 title "Physicochemical studies on solid dispersions of poorly water-soluble drugs" @default.
- W76252318 cites W102724740 @default.
- W76252318 cites W1502236593 @default.
- W76252318 cites W1964088776 @default.
- W76252318 cites W1967935934 @default.
- W76252318 cites W1968646744 @default.
- W76252318 cites W1995330870 @default.
- W76252318 cites W2004895912 @default.
- W76252318 cites W2011354686 @default.
- W76252318 cites W2014874223 @default.
- W76252318 cites W2015633580 @default.
- W76252318 cites W2026460968 @default.
- W76252318 cites W2027930286 @default.
- W76252318 cites W2031450493 @default.
- W76252318 cites W2040432233 @default.
- W76252318 cites W2054897747 @default.
- W76252318 cites W2060450041 @default.
- W76252318 cites W2070834364 @default.
- W76252318 cites W2071426487 @default.
- W76252318 cites W2076520305 @default.
- W76252318 cites W2079413731 @default.
- W76252318 cites W2082203116 @default.
- W76252318 cites W2084003639 @default.
- W76252318 cites W2088458504 @default.
- W76252318 cites W2093569268 @default.
- W76252318 cites W2142483595 @default.
- W76252318 doi "https://doi.org/10.1016/j.tca.2005.09.011" @default.
- W76252318 hasPublicationYear "2005" @default.
- W76252318 type Work @default.
- W76252318 sameAs 76252318 @default.
- W76252318 citedByCount "131" @default.
- W76252318 countsByYear W762523182012 @default.
- W76252318 countsByYear W762523182013 @default.
- W76252318 countsByYear W762523182014 @default.
- W76252318 countsByYear W762523182015 @default.
- W76252318 countsByYear W762523182016 @default.
- W76252318 countsByYear W762523182017 @default.
- W76252318 countsByYear W762523182018 @default.
- W76252318 countsByYear W762523182019 @default.
- W76252318 countsByYear W762523182020 @default.
- W76252318 countsByYear W762523182021 @default.
- W76252318 countsByYear W762523182022 @default.
- W76252318 countsByYear W762523182023 @default.
- W76252318 crossrefType "journal-article" @default.
- W76252318 hasAuthorship W76252318A5015819023 @default.
- W76252318 hasAuthorship W76252318A5019216041 @default.
- W76252318 hasAuthorship W76252318A5032405012 @default.
- W76252318 hasAuthorship W76252318A5044734486 @default.
- W76252318 hasAuthorship W76252318A5057836455 @default.
- W76252318 hasAuthorship W76252318A5059143159 @default.
- W76252318 hasAuthorship W76252318A5073844357 @default.
- W76252318 hasConcept C121332964 @default.
- W76252318 hasConcept C127413603 @default.
- W76252318 hasConcept C129446986 @default.
- W76252318 hasConcept C14029885 @default.
- W76252318 hasConcept C153294291 @default.
- W76252318 hasConcept C159985019 @default.
- W76252318 hasConcept C178790620 @default.
- W76252318 hasConcept C185592680 @default.
- W76252318 hasConcept C188027245 @default.
- W76252318 hasConcept C192562407 @default.
- W76252318 hasConcept C204530211 @default.
- W76252318 hasConcept C26771246 @default.
- W76252318 hasConcept C2776035855 @default.
- W76252318 hasConcept C2780077769 @default.
- W76252318 hasConcept C39519442 @default.
- W76252318 hasConcept C42360764 @default.
- W76252318 hasConcept C521977710 @default.
- W76252318 hasConcept C56052488 @default.
- W76252318 hasConcept C88380143 @default.
- W76252318 hasConcept C97355855 @default.
- W76252318 hasConceptScore W76252318C121332964 @default.
- W76252318 hasConceptScore W76252318C127413603 @default.
- W76252318 hasConceptScore W76252318C129446986 @default.
- W76252318 hasConceptScore W76252318C14029885 @default.
- W76252318 hasConceptScore W76252318C153294291 @default.
- W76252318 hasConceptScore W76252318C159985019 @default.
- W76252318 hasConceptScore W76252318C178790620 @default.
- W76252318 hasConceptScore W76252318C185592680 @default.
- W76252318 hasConceptScore W76252318C188027245 @default.
- W76252318 hasConceptScore W76252318C192562407 @default.
- W76252318 hasConceptScore W76252318C204530211 @default.
- W76252318 hasConceptScore W76252318C26771246 @default.
- W76252318 hasConceptScore W76252318C2776035855 @default.
- W76252318 hasConceptScore W76252318C2780077769 @default.
- W76252318 hasConceptScore W76252318C39519442 @default.
- W76252318 hasConceptScore W76252318C42360764 @default.