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- W76271618 endingPage "412" @default.
- W76271618 startingPage "387" @default.
- W76271618 abstract "Steroid hormones are essential regulators of a vast number of physiological processes. The biosynthesis of these chemical messengers occurs in specialized steroidogenic tissues via a multi-step process that is catalyzed by members of the cytochrome P450 superfamily of monooxygenases and hydroxysteroid dehydrogenases. Though numerous signaling mediators, including cytokines and growth factors control steroidogenesis, trophic peptide hormones are the primary regulators of steroid hormone production. These peptide hormones activate a cAMP/cAMP-dependent kinase (PKA) signaling pathway, however, studies have shown that crosstalk between multiple signal transduction pathways and signaling molecules modulates optimal steroidogenic capacity. Sphingolipids such as ceramide, sphingosine, sphingosine-1-phosphate, sphingomyelin, and gangliosides have been shown to control the steroid hormone biosynthetic pathway at multiple levels, including regulating steroidogenic gene expression and activity as well as acting as second messengers in signaling cascades. In this review, we provide an overview of recent studies that have investigated the role of sphingolipids in adrenal, gonadal, and neural steroidogenesis." @default.
- W76271618 created "2016-06-24" @default.
- W76271618 creator A5000519505 @default.
- W76271618 creator A5065059101 @default.
- W76271618 date "2008-08-26" @default.
- W76271618 modified "2023-10-02" @default.
- W76271618 title "Multiple Roles for Sphingolipids in Steroid Hormone Biosynthesis" @default.
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