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• W762731812 abstract "Hepatocellular carcinoma (HCC) is the fifth most frequent cancer worldwide, ranking third among all cancer-related mortalities in the world, indicating the importance to development of bioassays for evaluation of risk factors, prevention and treatment this malignancy. There are several animal models for the study of hepatocarcinogenesis using chemicals such as diethylnitrosamine (DEN), as an initiator for carcinogenesis, and carbon tetrachloride (CCl4) as a promoting agent. Various cell types have the capacity to synthesize/metabolize and/or it are stimulated by vitamin D (VD), including hepatocytes. Thus, there is a crescent evidence for relationship between VD deficiency and the development of liver disease, including HCC. Therefore, this study was conducted to evaluate the beneficial effect of VD3 supplementation on development of preneoplastic lesions (PNL) in the DEN/CCl4 model. Male Wistar rats were randomly divided into six groups (15 animals each). G1: untreated control group; G2-G6: groups received a single i.p. dose of diethylnitrosamine (DEN) and weekly intragastric administrations (i.g.) of carbon tetrachloride (CCl4); G3-G6: groups were submitted to DEN/CCl4 protocol and received VD3 supplementation at doses of 250, 500, 1000 and 1500 μg/kg, i.g., respectively, on alternate days for 16 weeks. At the end of week 18, the animals were euthanized and blood (AST and VD3 serum levels analysis) and liver (placental glutathione S-trasferase (GST-P)-positive PNL, KI-67 cell proliferation and vitamin D receptor (VDR) analysis) samples were collected. Groups receiving 1000 and 1500 μg/kg vitamin D3 presented significantly lower mean body weight evolution and food intake (p 1,0 mm) was significantly lower (p< 0,001) in the groups G3 to G6 when compared to the group G2, without a clear dose-response. In addition, the hepatic cell proliferation levels (Ki-67) were significantly lower in groups G5 and G6 when compared to the groups G1 and G2, but without an increase in VDR protein levels. High doses of VD3 supplementation (1000 and 1500 μg/kg) has beneficial effects against GST-P-positive PNL and cell proliferation induced in the DEN/CCl4 model used." @default.
• W762731812 created "2016-06-24" @default.
• W762731812 creator A5049106658 @default.
• W762731812 date "2014-02-28" @default.
• W762731812 modified "2023-09-24" @default.
• W762731812 title "EFEITO DA SUPLEMENTAÇÃO DE VITAMINA D NO DESENVOLVIMENTO DE LESÕES PRÉ-NEOPLÁSICAS QUIMICAMENTE INDUZIDAS EM RATOS WISTAR MACHO." @default.
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