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- W763007482 abstract "The pharmacokinetics of oral nifedipine (5 mg/kg) was studied in rabbits given after or simultaneously with naringin (1.5, 7.5 and 15 mg/kg, respectively). The area under the plasma concentration-time curve (AUC) and the peak concentration of nifedipine coadministered or pretreated with naringin were significantly increased (p of nifedipine. It is suggested that naringin may alter pharmacokinetic paramiters of nifedipine by inhibition of P-glycoprotein efflux pump and its first-pass metabolism. The dosage of nifedipine should be adjusted when it is administered with naringin in a clinical situation." @default.
- W763007482 created "2016-06-24" @default.
- W763007482 date "2005-04-20" @default.
- W763007482 modified "2023-09-26" @default.
- W763007482 title "Effect of Naringin on the Pharmacokinetics of Nifedipine in Rabbits" @default.
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- W763007482 doi "https://doi.org/10.4333/kps.2005.35.2.101" @default.
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