FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W763041070> ?p ?o ?g. }

• W763041070 endingPage "531" @default.
• W763041070 startingPage "519" @default.
• W763041070 abstract "Recurrence and death in a significant number of patients with ERα-positive breast cancer occurs 10–20 years after diagnosis. Prognostic markers for late events have been more elusive. TFAP2C (AP2γ) regulates the expression of ERα, the ERα pioneer factors FOXA1 and GATA3, and controls ERα-dependent transcription. The purpose of this investigation is to determine the long-term prognostic value of TFAP2C. A tissue microarray (TMA) consisting of breast tumors from 451 patients with median follow-up time of 10.3 years was created and tested for the expression of TFAP2C by immunohistochemistry. Wilcoxon Rank-Sum and Kruskal–Wallis tests were used to determine if TFAP2C H-scores correlate with other tumor markers. Cox proportional hazards regression models were used to determine whether TFAP2C H-scores and other tumor markers were related to overall and disease-free survival in univariate and multivariable models. TFPAC2 overexpression did not impact overall survival during the first 10 years after diagnosis, but was associated with a shorter survival after 10 years (HR 3.40, 95 % CI 1.58, 7.30; p value = 0.002). This late divergence persisted in ER-positive (HR 2.86, 95 % CI 1.29, 6.36; p value = 0.01) and endocrine therapy-positive subgroups (HR 4.19, 95 % CI 1.72, 10.23; p value = 0.002). For the ER+ and endocrine therapy subgroup, the HR was 3.82 (95 % CI 1.53, 9.50; p value = 0.004). TFAP2C H-scores were not correlated with other tumor markers or related to disease-free survival. In this hypothesis-generating study, we show that higher TFAP2C scores correlate with poor overall survival after 10 years of diagnosis in ERα-positive and endocrine therapy-treated subgroups." @default.
• W763041070 created "2016-06-24" @default.
• W763041070 creator A5006346528 @default.
• W763041070 creator A5011938575 @default.
• W763041070 creator A5061385868 @default.
• W763041070 creator A5066442050 @default.
• W763041070 creator A5067038478 @default.
• W763041070 creator A5068666503 @default.
• W763041070 creator A5077837457 @default.
• W763041070 creator A5080410100 @default.
• W763041070 date "2015-07-10" @default.
• W763041070 modified "2023-09-30" @default.
• W763041070 title "TFAP2C expression in breast cancer: correlation with overall survival beyond 10 years of initial diagnosis" @default.
• W763041070 cites W1482226454 @default.
• W763041070 cites W1562190372 @default.
• W763041070 cites W1607267312 @default.
• W763041070 cites W1965514686 @default.
• W763041070 cites W1966403355 @default.
• W763041070 cites W1976121925 @default.
• W763041070 cites W1976967103 @default.
• W763041070 cites W1982378557 @default.
• W763041070 cites W1993299801 @default.
• W763041070 cites W1998162919 @default.
• W763041070 cites W2002262418 @default.
• W763041070 cites W2005895632 @default.
• W763041070 cites W2010503849 @default.
• W763041070 cites W2012468520 @default.
• W763041070 cites W2012614526 @default.
• W763041070 cites W2013956549 @default.
• W763041070 cites W2021145743 @default.
• W763041070 cites W2034032177 @default.
• W763041070 cites W2037768911 @default.
• W763041070 cites W2041970562 @default.
• W763041070 cites W2048015102 @default.
• W763041070 cites W2056242601 @default.
• W763041070 cites W2060259004 @default.
• W763041070 cites W2060860909 @default.
• W763041070 cites W2070286724 @default.
• W763041070 cites W2072761001 @default.
• W763041070 cites W2073367400 @default.
• W763041070 cites W2076974754 @default.
• W763041070 cites W2077852227 @default.
• W763041070 cites W2081562657 @default.
• W763041070 cites W2088160256 @default.
• W763041070 cites W2088280645 @default.
• W763041070 cites W2088717951 @default.
• W763041070 cites W2098408143 @default.
• W763041070 cites W2105341311 @default.
• W763041070 cites W2109388713 @default.
• W763041070 cites W2111324624 @default.
• W763041070 cites W2111758831 @default.
• W763041070 cites W2111891435 @default.
• W763041070 cites W2125772206 @default.
• W763041070 cites W2129638021 @default.
• W763041070 cites W2131994307 @default.
• W763041070 cites W2132846837 @default.
• W763041070 cites W2141717219 @default.
• W763041070 cites W2143201020 @default.
• W763041070 cites W2143283599 @default.
• W763041070 cites W2149441684 @default.
• W763041070 cites W2150533948 @default.
• W763041070 cites W2156933633 @default.
• W763041070 cites W2159216027 @default.
• W763041070 cites W2161991320 @default.
• W763041070 cites W2162235294 @default.
• W763041070 cites W2466792968 @default.
• W763041070 cites W4231356616 @default.
• W763041070 doi "https://doi.org/10.1007/s10549-015-3492-2" @default.
• W763041070 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26160249" @default.
• W763041070 hasPublicationYear "2015" @default.
• W763041070 type Work @default.
• W763041070 sameAs 763041070 @default.
• W763041070 citedByCount "31" @default.
• W763041070 countsByYear W7630410702016 @default.
• W763041070 countsByYear W7630410702017 @default.
• W763041070 countsByYear W7630410702018 @default.
• W763041070 countsByYear W7630410702019 @default.
• W763041070 countsByYear W7630410702020 @default.
• W763041070 countsByYear W7630410702021 @default.
• W763041070 countsByYear W7630410702022 @default.
• W763041070 countsByYear W7630410702023 @default.
• W763041070 crossrefType "journal-article" @default.
• W763041070 hasAuthorship W763041070A5006346528 @default.
• W763041070 hasAuthorship W763041070A5011938575 @default.
• W763041070 hasAuthorship W763041070A5061385868 @default.
• W763041070 hasAuthorship W763041070A5066442050 @default.
• W763041070 hasAuthorship W763041070A5067038478 @default.
• W763041070 hasAuthorship W763041070A5068666503 @default.
• W763041070 hasAuthorship W763041070A5077837457 @default.
• W763041070 hasAuthorship W763041070A5080410100 @default.
• W763041070 hasBestOaLocation W7630410702 @default.
• W763041070 hasConcept C121608353 @default.
• W763041070 hasConcept C126322002 @default.
• W763041070 hasConcept C143998085 @default.
• W763041070 hasConcept C50382708 @default.
• W763041070 hasConcept C530470458 @default.
• W763041070 hasConcept C71924100 @default.
• W763041070 hasConceptScore W763041070C121608353 @default.

• next