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- W7633178 abstract "2023 Objectives Ventilation/Perfusion SPECT (V/Q) is a procedure with high sensitivity for detection of pulmonary embolism. The application of low-dose-CT from SPECT-CT increases specificity of V/Q SPECT (1). Using µ-maps from low-dose-CT SPECT reconstruction can be done with and without attenuation correction (AC). In general AC leads to homogenisation of tracer distribution. Aim was to quantify the influence of AC on the homogeneity of V/Q-SPECT, as a marked homogenisation should ease recognition of pathological findings. Methods Data from 20 patients (routine V/Q-SPECT-CT to rule out pulmonary embolism) with normal findings were enrolled. V-SPECT: appr. 40 MBq 99mTc-Technegas, 24sec/proj.; Q-SPECT: 179±30 MBq Tc-99m-MAA, 8sec/proj.; subsequently low-dose-CT (SymbiaT, Siemens) was done in all patients. Iterative Flash3D reconstruction with and without AC. Analysis of all V/Q-SPECT data with PMOD. VOIs: 15% isocontour in P-SPECT, basal sections were omitted. Variation coefficients of count densities (VC) were calculated lungwise in the defined VOIs for AC and non-AC data. T-test, p Results The VCs in the AC V/Q-SPECT data were slightly lower than those in the non AC data. Ventilation: right 41.0±6.8% (AC) vs. 42.1±5.3% (nonAC) (p=0.24), left: 41.3±4.4% (AC) vs. 44.4±4.3% (nonAC) (p Conclusions In V/Q-SPECT-CT AC increases homogeneity of the images only very slightly. As such, using AC during reconstruction does not seem to be clinically advantageous. Bearing in mind the possibility of a misalignment between SPECT and CT - which could lead to over- or under-correction - we conclude that the combination of non-AC V/Q-SPECT-data with low-dose CT only for anatomical reasons is the most reliable diagnostic option. 1. Gutte H, J Nucl Med 2009, 1987-92" @default.
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- W7633178 date "2013-05-01" @default.
- W7633178 modified "2023-09-28" @default.
- W7633178 title "Lung ventilation/perfusion SPECT-CT: Influence of attenuation correction on homogeneity of SPECT data" @default.
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