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• W763687319 endingPage "133" @default.
• W763687319 startingPage "113" @default.
• W763687319 abstract "The anticodon stem loop of tRNA is one of the most remarkable hairpins in RNAs that present several modified nucleotides arising by posttranscriptional processes. Many different modifications have been identified at position 34. These modifications are considered to be important for the specificity, fidelity, and efficiency of the tRNA functions, mainly in decoding the genetic message during translation on the ribosome. This chapter summarizes the information available about the role of modified nucleotides present at positions 34 and 37 in modulating tRNA anticodon-anticodon interaction. Implications for codon-anticodon interaction and comparison with other types of RNA-RNA interacting systems are also discussed in this chapter. One way to evaluate the effect of modified nucleotides on the stability and dynamic properties of anticodon-anticodon complexes is the temperature-jump relaxation technique. The chapter describes two RNA loop-loop interacting systems that do not involve modified nucleotides. Their comparison with the loop-loop interacting systems involving hairpins of tRNA molecules described in this chapter are interesting to better understand how modified nucleotides can restrict the interaction to only a few selected nucleotides within the interacting RNA loops. Comparison to other types of loop-loop complexes involving RNAs other than tRNAs, the so-called “kissing” complexes, is also made. The main difference between these different types of loop-loop complexes is the extent of base pairing between the nucleotides of the interacting loops." @default.
• W763687319 created "2016-06-24" @default.
• W763687319 creator A5024980365 @default.
• W763687319 creator A5039499102 @default.
• W763687319 creator A5067744333 @default.
• W763687319 creator A5073956638 @default.
• W763687319 date "2014-04-30" @default.
• W763687319 modified "2023-09-24" @default.
• W763687319 title "Modulatory Role of Modified Nucleotides in RNA Loop-Loop Interaction" @default.
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