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- W76378212 abstract "To date a considerable number of oncogenes have been identified and have had their proto-oncogene counterparts cloned. In general the induction of proto-oncogenes, for example c-fos, is rapid, transient, and protein synthesis independent (see references in Hughes and Dragunow 1995; Morgan 1991; Morgan and Curran 1995). There are considered to be at least two different pathways leading to the induction of c-fos, as established from cell culture, one involving the activation of the inositol-phosphate-protein kinase C pathway (the serum response element) and the other involving an increase in intracellular calcium. It is considered that the proteins involved in the induction of c-fos transcription require only posttranslational modification (phosphorylation) for activation, thus at least partly explaining the rapid induction of c-fos. Since protein synthesis inhibition results in a huge induction of c-fos mRNA, it is suggested that a de novo synthesized protein is required for the “shut off” of c-fos transcription (see references in HUGHES and Dragunow 1995). The protein responsible for the transcriptional “shut off” is the c-fos protein product, Fos; however, such a negative feedback mechanism (trans-repression) influences only c-fos serum-inducible promoter elements. In addition to trans-repression, the induction of c-fos is also transient due to untranslated AT-rich sequences within the transcript which reduce c-fos stability (see references in Hughes and Dragunow 1995)." @default.
- W76378212 created "2016-06-24" @default.
- W76378212 creator A5024563142 @default.
- W76378212 creator A5056963078 @default.
- W76378212 date "1997-01-01" @default.
- W76378212 modified "2023-09-23" @default.
- W76378212 title "Pharmacological Studies of Nociceptive Systems Using the C-Fos Immunohistochemical Technique: An Indicator of Noxiously Activated Spinal Neurones" @default.
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