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- W76386317 abstract "The initial attempt to include chemotherapy as an adjuvant to surgery in treating patients with breast cancer occurred in 1958. It consisted of an NSABP trial to measure the impact of perioperative thiotepa on relapse-free and overall survival of patients with node-positive breast cancer who were undergoing a radical mastectomy. A second early adjuvant study was conducted by Roar Nissen-Meyer in Norway in 1965. He evaluated the effect of perioperative cyclophosphamide on the survival of patients with node-positive breast cancer. Though results were minimally positive in premenopausal women with one to three positive nodes, these trials did not generate a great deal of enthusiasm. In fact, the perioperative delivery of adjuvant chemotherapy was fundamentally flawed because it was based on the misconception that metastases occurred when small clumps of tumor cells were released from the breast into the circulation during mastectomy." @default.
- W76386317 created "2016-06-24" @default.
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- W76386317 date "2014-01-01" @default.
- W76386317 modified "2023-09-23" @default.
- W76386317 title "Adjuvant Therapy Advances" @default.
- W76386317 doi "https://doi.org/10.1016/b978-0-12-420153-8.00004-7" @default.
- W76386317 hasPublicationYear "2014" @default.
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