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- W764002562 abstract "Proc Amer Assoc Cancer Res, Volume 47, 20064544 Purpose: Recently, the somatic mutations in tyrosine kinase (TK) domain of epidermal growth factor receptor (EGFR) gene has been identified as predictor of tumor response to gefitinib or erlotinib in non-small-cell lung cancer (NSCLC). Also, much evidence has accumulated that the EGFR are strongly implicated in the development of lung adenocarcinoma (ADC). However, the frequency of these mutations in pulmonary precancerous lesion such as atypical hyperplasia (AAH) was unknown. Purpose of this study is to elucidate the implication of EGFR mutation in the early carcinogenesis of lung cancer. Methods: We retrospectively examined the EGFR mutations in 9 AAH and 31 adenocarcinoma (ADC) lesions obtained from 34 Japanese patients who were treated with surgery. The EGFR gene mutations in exon 18 - 21 were analyzed with polymerase chain reaction and direct sequence methods. All patients with AAH were female. Nine were male and 25 were female with ADC. Nine patients had synchronous or metachronous multiple lesions. One patient had synchronous triple ADC’s, two patients had synchronous double ADC’s, two patients had metachronous two ADC, and three patients hsd synchronous AAH and ADC. Results: EGFR mutations were detected in four (44%) of nine AAH lesions and seven (23%) of 31 ADC lesions (P=0.34). One of each lesions were revealed to harbor new unknown EGFR mutation. In nine patients who had multiple lesions, six patients harbored the EGFR gene mutation. However the patterns of EGFR gene mutation in multiple lesions of same patient were not identical. For example, synchronous AAH and ADC in one patient harbored same point mutation in exon 19, however, additional point mutation in exon 20 was also detected in this AAH lesion. Conclusions: Frequency of EGFR TK domain mutations in AAH and ADC were similar. Multiple lesions in same patient did not always harbored same EGFR gene mutations. These results indicate that these EGFR mutations occurred early phase of lung carcinogenesis such as AAH" @default.
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- W764002562 date "2006-04-15" @default.
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- W764002562 title "Early occurrence of epidermal growth factor receptor Mutation in lung adenocarcinoma: Comparison between pulmonary atypical adenomatous hyperplasia and adenocarcinoma" @default.
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