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- W764793567 abstract "Objective To establish objective criteria for the grading of liver function and prognosis through analyses of serum albumin, prealbumin, total bile acid, cholesterol, prothrombin time and prothrombin activity. Methods 108 patients with chronic hepatopathy were divided into 3 groups according to the modified Child-Pugh classification (group Child A, Child B and Child C). There were 24 patients in the control group. Blood from the median cubital vein was taken for detecting the levels of total serum protein, albumin, prealbumin, total bilirubin, total bile acid, cholesterol, and prothrombin activity. Abdominal sonography was performed to examine the liver, spleen, the width of portal vein's width, and ascites. Results ①In group Child A, Child B and Child C, the average serum albumin levels were 35.9, 29.1 and 26mg/L respectively. Prealbumin level: 207, 110.2 and 76.2mg/L; Cholesterol: 4.5, 3.6 and 2.3nmol/L. These values were significantly lower (P＜0.05) compared with the control group. ②The total bile acid level in group Child A, Child B and Child C were 13.4, 31.5 and 58.53 μmol/L respectively, which had no statistical difference among the three groups. ③The prothrombin time in the three groups were 14.5, 15.7 and 20.2s, and there was no statistical difference between group Child A and Child B. However, significant difference (P＜0.05) were found for the prothrombin activities among the three groups (84.1%, 62% and 37.7%). ④For the six patients in Group Child C who finally died, serum prealbumin was ＜100mg/L, totai bile acid ＞30μmol/L, cholesterol ＜2.5mmol/L and prothrombin activity was ＜40%. Conclusion The serum albumin is in accordance with the modified Child-Pugh classification, while the prothrombin time and serum bilirubin have little significance for grading The serum prealbumin, total bile acid, cholesterol, and prothrombin activity are the more objective criteria for the grading of liver function and prognosis." @default.
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- W764793567 date "2009-01-10" @default.
- W764793567 modified "2023-09-24" @default.
- W764793567 title "前白蛋白、总胆汁酸、凝血酶原活动度及胆固醇检测对肝功能分期及判断预后的临床意义" @default.
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