Matches in SemOpenAlex for { <https://semopenalex.org/work/W765210530> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W765210530 abstract "Chronic wounds represent a severe socio-economic burden and a key area of unmet clinical need. PKC? is ubiquitous in the skin, particularly the epidermis and functions in numerous pathways that are fundamental to wound repair. By utilising a global PKC?-/- mouse we have identified PKC?-regulated processes both in unwounded skin and during wound healing. PKC?-/- mice display considerably delayed wound healing with a dramatic reduction in re-epithelialisation. By analysing the ultrastructure of the epidermis, I have shown that this delay directly correlates with a failure of wound edge desmosomes to switch to a their adhesive properties. A major risk factor for the development of chronic wounds is age. Crucially, this delay in modulating cell adhesion is conserved in human chronic wounds and aged murine skin. Furthermore, manipulation of PKC? using an inducible bitransgenic mouse containing epidermal specific constitutively active PKC? can accelerate the modulation of desmosome adhesion and subsequently improve re-epithelialisation. Global gene expression analysis of PKC?-/- skin and wounds revealed further defects. Upon wounding, we observed a failure to correctly regulate expression of key collagen and Wnt signalling genes that are essential for correct and timely wound healing. Finally, intrinsic gene expression changes were identified in the skin of PKC?-/- mice, specifically a downregulation of multiple extracellular matrix genes. Of note was the downregulation of small leucine-rich proteoglycans which led to alterations to dermal collagen structure and skin tensile strength. These changes render the PKC?-/- skin susceptible to breaking and wound development. To conclude, we have identified multiple roles for PKC? intrinsically in the skin and also during cutaneous wound healing. Importantly, these intrinsic changes appear to predispose PKC?-/- skin to the development of cutaneous wounds and altered wound-specific processes that manifest in a delayed healing phenotype." @default.
- W765210530 created "2016-06-24" @default.
- W765210530 creator A5008299672 @default.
- W765210530 date "2014-01-19" @default.
- W765210530 modified "2023-09-23" @default.
- W765210530 title "The role of Protein Kinase Cα in the skin and cutaneous wound healing" @default.
- W765210530 hasPublicationYear "2014" @default.
- W765210530 type Work @default.
- W765210530 sameAs 765210530 @default.
- W765210530 citedByCount "0" @default.
- W765210530 crossrefType "dissertation" @default.
- W765210530 hasAuthorship W765210530A5008299672 @default.
- W765210530 hasConcept C104317684 @default.
- W765210530 hasConcept C105702510 @default.
- W765210530 hasConcept C127561419 @default.
- W765210530 hasConcept C137620995 @default.
- W765210530 hasConcept C137738243 @default.
- W765210530 hasConcept C1491633281 @default.
- W765210530 hasConcept C185592680 @default.
- W765210530 hasConcept C189165786 @default.
- W765210530 hasConcept C190567982 @default.
- W765210530 hasConcept C195794163 @default.
- W765210530 hasConcept C203014093 @default.
- W765210530 hasConcept C2776458125 @default.
- W765210530 hasConcept C2780269544 @default.
- W765210530 hasConcept C54355233 @default.
- W765210530 hasConcept C62478195 @default.
- W765210530 hasConcept C71924100 @default.
- W765210530 hasConcept C86803240 @default.
- W765210530 hasConcept C95444343 @default.
- W765210530 hasConceptScore W765210530C104317684 @default.
- W765210530 hasConceptScore W765210530C105702510 @default.
- W765210530 hasConceptScore W765210530C127561419 @default.
- W765210530 hasConceptScore W765210530C137620995 @default.
- W765210530 hasConceptScore W765210530C137738243 @default.
- W765210530 hasConceptScore W765210530C1491633281 @default.
- W765210530 hasConceptScore W765210530C185592680 @default.
- W765210530 hasConceptScore W765210530C189165786 @default.
- W765210530 hasConceptScore W765210530C190567982 @default.
- W765210530 hasConceptScore W765210530C195794163 @default.
- W765210530 hasConceptScore W765210530C203014093 @default.
- W765210530 hasConceptScore W765210530C2776458125 @default.
- W765210530 hasConceptScore W765210530C2780269544 @default.
- W765210530 hasConceptScore W765210530C54355233 @default.
- W765210530 hasConceptScore W765210530C62478195 @default.
- W765210530 hasConceptScore W765210530C71924100 @default.
- W765210530 hasConceptScore W765210530C86803240 @default.
- W765210530 hasConceptScore W765210530C95444343 @default.
- W765210530 hasLocation W7652105301 @default.
- W765210530 hasOpenAccess W765210530 @default.
- W765210530 hasPrimaryLocation W7652105301 @default.
- W765210530 hasRelatedWork W1972912753 @default.
- W765210530 hasRelatedWork W1997268943 @default.
- W765210530 hasRelatedWork W2002191327 @default.
- W765210530 hasRelatedWork W2004185349 @default.
- W765210530 hasRelatedWork W2004222333 @default.
- W765210530 hasRelatedWork W2016074728 @default.
- W765210530 hasRelatedWork W2041795914 @default.
- W765210530 hasRelatedWork W2050006226 @default.
- W765210530 hasRelatedWork W2052983487 @default.
- W765210530 hasRelatedWork W2057546941 @default.
- W765210530 hasRelatedWork W2086180233 @default.
- W765210530 hasRelatedWork W2100157988 @default.
- W765210530 hasRelatedWork W2107324803 @default.
- W765210530 hasRelatedWork W2149541378 @default.
- W765210530 hasRelatedWork W2396678655 @default.
- W765210530 hasRelatedWork W2472286572 @default.
- W765210530 hasRelatedWork W2607322087 @default.
- W765210530 hasRelatedWork W2612098227 @default.
- W765210530 hasRelatedWork W2806145459 @default.
- W765210530 hasRelatedWork W2982203951 @default.
- W765210530 isParatext "false" @default.
- W765210530 isRetracted "false" @default.
- W765210530 magId "765210530" @default.
- W765210530 workType "dissertation" @default.