Matches in SemOpenAlex for { <https://semopenalex.org/work/W76529230> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W76529230 abstract "Acquired immune responses are shaped by the nature and activation status of dendritic cell (DC) subpopulations in the lymph node. To better understand the process of DC accumulation in the lymph node during infection we examined the importance of several proinflammatory cytokines and mast cells, which can be a potent source of factors that promote accumulation of DC in the lymph node. The number of plasmacytoid DC (pDC), CD8+ DC and CD11b+ DC in the lymph nodes that drained the site of intradermal injection of S. aureus peptidoglycan (PGN) or saline was determined at 18h post injection. To examine the importance of tumor necrosis factor (TNF), interleukin (IL)1α/β and IL-6 in PGN induced DC recruitment, we assayed responses in mice deficient in these mediators. TNF and IL-1 receptor were dispensable for the accumulation of pDC, CD8+ DC and CD11b+ DC in response to PGN. IL-6 deficient mice had significantly reduced accumulation of CD11b+ DC. Examination of responses to PGN in mast cell deficient mice and mice locally reconstituted with mast cells revealed that mast cells are essential for the optimal recruitment of CD8+ DC and pDC, but not the IL-6 dependent CD11b+ DC subset. These data suggest that PGN activated mast cells can drive the accumulation of DC subpopulations in the lymph node and thus could play a role in modulating the ensuing acquired immune responses. This work is funded by the Canadian Institutes of Health Research." @default.
- W76529230 created "2016-06-24" @default.
- W76529230 creator A5003505707 @default.
- W76529230 creator A5038643576 @default.
- W76529230 date "2008-03-01" @default.
- W76529230 modified "2023-09-27" @default.
- W76529230 title "Mast cells and interleukin‐6 are required for the optimal accumulation of dendritic cell subpopulations in the lymph node in response to bacterial peptidoglycan" @default.
- W76529230 doi "https://doi.org/10.1096/fasebj.22.1_supplement.675.6" @default.
- W76529230 hasPublicationYear "2008" @default.
- W76529230 type Work @default.
- W76529230 sameAs 76529230 @default.
- W76529230 citedByCount "0" @default.
- W76529230 crossrefType "journal-article" @default.
- W76529230 hasAuthorship W76529230A5003505707 @default.
- W76529230 hasAuthorship W76529230A5038643576 @default.
- W76529230 hasConcept C142724271 @default.
- W76529230 hasConcept C164027704 @default.
- W76529230 hasConcept C167672396 @default.
- W76529230 hasConcept C17991360 @default.
- W76529230 hasConcept C203014093 @default.
- W76529230 hasConcept C2776090121 @default.
- W76529230 hasConcept C2776914184 @default.
- W76529230 hasConcept C2778170410 @default.
- W76529230 hasConcept C2779720271 @default.
- W76529230 hasConcept C2779726688 @default.
- W76529230 hasConcept C2780849966 @default.
- W76529230 hasConcept C71924100 @default.
- W76529230 hasConcept C86803240 @default.
- W76529230 hasConcept C8891405 @default.
- W76529230 hasConcept C95444343 @default.
- W76529230 hasConceptScore W76529230C142724271 @default.
- W76529230 hasConceptScore W76529230C164027704 @default.
- W76529230 hasConceptScore W76529230C167672396 @default.
- W76529230 hasConceptScore W76529230C17991360 @default.
- W76529230 hasConceptScore W76529230C203014093 @default.
- W76529230 hasConceptScore W76529230C2776090121 @default.
- W76529230 hasConceptScore W76529230C2776914184 @default.
- W76529230 hasConceptScore W76529230C2778170410 @default.
- W76529230 hasConceptScore W76529230C2779720271 @default.
- W76529230 hasConceptScore W76529230C2779726688 @default.
- W76529230 hasConceptScore W76529230C2780849966 @default.
- W76529230 hasConceptScore W76529230C71924100 @default.
- W76529230 hasConceptScore W76529230C86803240 @default.
- W76529230 hasConceptScore W76529230C8891405 @default.
- W76529230 hasConceptScore W76529230C95444343 @default.
- W76529230 hasFunder F4320334506 @default.
- W76529230 hasIssue "S1" @default.
- W76529230 hasLocation W765292301 @default.
- W76529230 hasOpenAccess W76529230 @default.
- W76529230 hasPrimaryLocation W765292301 @default.
- W76529230 hasRelatedWork W1984305258 @default.
- W76529230 hasRelatedWork W1994284968 @default.
- W76529230 hasRelatedWork W2000342552 @default.
- W76529230 hasRelatedWork W2125951189 @default.
- W76529230 hasRelatedWork W2154542694 @default.
- W76529230 hasRelatedWork W2165578318 @default.
- W76529230 hasRelatedWork W2313033156 @default.
- W76529230 hasRelatedWork W2367344610 @default.
- W76529230 hasRelatedWork W2473523216 @default.
- W76529230 hasRelatedWork W3036604574 @default.
- W76529230 hasVolume "22" @default.
- W76529230 isParatext "false" @default.
- W76529230 isRetracted "false" @default.
- W76529230 magId "76529230" @default.
- W76529230 workType "article" @default.