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- W76529635 abstract "Tumor invasion and metastasis are the hallmarks of advanced stage cancer and are associated with poor patient prognosis. EGFR is overexpressed in a variety of tumor types and this frequently correlates with a more aggressive tumor phenotype. In this chapter, we discuss the cellular and molecular mechanisms by which EGFR contributes to tumor progression and present evidence from experimental and clinical observations that reinforce the notion that EGFR actively contributes to the onset of metastatic disease. EGFR plays a key role in the regulation of processes central to tumor invasion including cell adhesion and motility through its interactions with molecules such as integrins, cadherins, phospholipase Cγ1 and phosphoinositide 3-kinase. In addition, EGFR signaling can contribute to both proteolysis and angiogenesis through up-regulated expression of matrix metalloproteinases (MMPs) and angiogenic cytokines e.g. VEGF-A and IL-8. The significance of these contributions to tumor invasion and metastasis is highlighted by the fact that a mutant, constitutively active receptor (EGFRvIII) associated with human cancers can induce these behaviors when transfected into fibroblasts. Finally, we discuss the use of EGFR antagonists to stem metastatic disease and their potential, in combination with additional novel agents, to improve treatment for cancer patients." @default.
- W76529635 created "2016-06-24" @default.
- W76529635 creator A5024458263 @default.
- W76529635 creator A5025972115 @default.
- W76529635 creator A5027037729 @default.
- W76529635 creator A5072227079 @default.
- W76529635 date "2008-01-01" @default.
- W76529635 modified "2023-09-25" @default.
- W76529635 title "EGFR signaling in invasion, angiogenesis and metastasis" @default.
- W76529635 cites W1484020898 @default.
- W76529635 cites W1524954611 @default.
- W76529635 cites W1525911149 @default.
- W76529635 cites W1577573926 @default.
- W76529635 cites W1838340609 @default.
- W76529635 cites W1839381104 @default.
- W76529635 cites W1934347187 @default.
- W76529635 cites W1944354882 @default.
- W76529635 cites W1964108360 @default.
- W76529635 cites W1964595762 @default.
- W76529635 cites W1967941200 @default.
- W76529635 cites W1968826282 @default.
- W76529635 cites W1970979847 @default.
- W76529635 cites W1971541515 @default.
- W76529635 cites W1972134646 @default.
- W76529635 cites W1973498312 @default.
- W76529635 cites W1974045870 @default.
- W76529635 cites W1975322467 @default.
- W76529635 cites W1976329755 @default.
- W76529635 cites W1978266089 @default.
- W76529635 cites W1979346765 @default.
- W76529635 cites W1981873122 @default.
- W76529635 cites W1982174962 @default.
- W76529635 cites W1982380702 @default.
- W76529635 cites W1983609115 @default.
- W76529635 cites W1986241068 @default.
- W76529635 cites W1986727868 @default.
- W76529635 cites W1986827304 @default.
- W76529635 cites W1989658262 @default.
- W76529635 cites W1989900133 @default.
- W76529635 cites W1990669035 @default.
- W76529635 cites W1992885568 @default.
- W76529635 cites W1993059245 @default.
- W76529635 cites W1996017815 @default.
- W76529635 cites W1997889852 @default.
- W76529635 cites W2000217512 @default.
- W76529635 cites W2003736915 @default.
- W76529635 cites W2006154529 @default.
- W76529635 cites W2008483037 @default.
- W76529635 cites W2008634387 @default.
- W76529635 cites W2009532293 @default.
- W76529635 cites W2012095617 @default.
- W76529635 cites W2013631005 @default.
- W76529635 cites W2015039243 @default.
- W76529635 cites W2015314629 @default.
- W76529635 cites W2016302051 @default.
- W76529635 cites W2020065664 @default.
- W76529635 cites W2022185594 @default.
- W76529635 cites W2023898364 @default.
- W76529635 cites W2028586185 @default.
- W76529635 cites W2029344085 @default.
- W76529635 cites W2030201335 @default.
- W76529635 cites W2031626005 @default.
- W76529635 cites W2032050847 @default.
- W76529635 cites W2033443838 @default.
- W76529635 cites W2033989449 @default.
- W76529635 cites W2036750340 @default.
- W76529635 cites W2038126788 @default.
- W76529635 cites W2038246466 @default.
- W76529635 cites W2043760057 @default.
- W76529635 cites W2047700479 @default.
- W76529635 cites W2049424656 @default.
- W76529635 cites W2050247332 @default.
- W76529635 cites W2050888224 @default.
- W76529635 cites W2051109754 @default.
- W76529635 cites W2051120695 @default.
- W76529635 cites W2051571748 @default.
- W76529635 cites W2051982497 @default.
- W76529635 cites W2052943534 @default.
- W76529635 cites W2054566768 @default.
- W76529635 cites W2056464773 @default.
- W76529635 cites W2061385217 @default.
- W76529635 cites W2064047613 @default.
- W76529635 cites W2064411813 @default.
- W76529635 cites W2069185570 @default.
- W76529635 cites W2071601082 @default.
- W76529635 cites W2071860638 @default.
- W76529635 cites W2073042812 @default.
- W76529635 cites W2076243964 @default.
- W76529635 cites W2079399000 @default.
- W76529635 cites W2079668582 @default.
- W76529635 cites W2080069774 @default.
- W76529635 cites W2081293865 @default.
- W76529635 cites W2082454341 @default.
- W76529635 cites W2082634656 @default.
- W76529635 cites W2083354090 @default.
- W76529635 cites W2085370267 @default.
- W76529635 cites W2086240498 @default.
- W76529635 cites W2086528927 @default.