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- W765380056 abstract "Tho1 is a RNA-binding protein that assembles co-transcriptionally onto the nascent mRNA and is thought to be involved in mRNP biogenesis and mature mRNA export to cytoplasm in budding yeast. In fission yeast Schizosaccharomyces pombe, a homologue of THO1 (spTho1) was identified based on sequence alignment. A deletion mutant in a diploid strain was constructed by replacing one of spTho1-coding region with an ura4 + gene using one-step gene disruption method. Tetrad analysis showed that the spTho1 was not essential for growth. The spTho1 null mutant did not show any defects of bulk mRNA export. However, over-expression of spTho1 from strong nmt1 promoter caused the growth defects and accumulation of poly(A) + RNA in the nucleus. These results suggest that spTho1 is involved in mRNA export from the nucleus to cytoplasm though it is not essential." @default.
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- W765380056 date "2010-01-01" @default.
- W765380056 modified "2023-09-24" @default.
- W765380056 title "Effects of spTho1 Deletion and Over-Expression on mRNA Export in Fission Yeast" @default.
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