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- W76544648 abstract "Prions are unprecedented transmissible pathogenic agents that cause a group of fatal neurodegenerative diseases, including Creutzfeldt-Jakob disease (CJD) and kuru in humans, bovine spongiform encephalopathy (BSE) in cattle, chronic wasting disease (CWD) in deer and elk, and scrapie in sheep and goats. Prions are resistant to standard disinfection and sterilization procedures validated against viruses and bacteria. There are well documented cases of iatrogenic prion transmission from surgical instruments and cadaveric tissue. The lack of noncorrosive procedures that inactivate prions is a cause for concern for hospital infection-control departments. A novel method to inactivate human prions completely, using sodium dodecyl sulfate at acidic pH (acidic SDS), is reported here. Prion inactivation was demonstrated on both brain homogenate and on the surface of contaminated surgical stainless steel, the latter of which proved significantly more resistant to inactivation." @default.
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- W76544648 date "2007-09-07" @default.
- W76544648 modified "2023-09-26" @default.
- W76544648 title "Disinfection of Prions" @default.
- W76544648 doi "https://doi.org/10.1021/bk-2007-0967.ch003" @default.
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