Matches in SemOpenAlex for { <https://semopenalex.org/work/W765497804> ?p ?o ?g. }
- W765497804 endingPage "1158" @default.
- W765497804 startingPage "1152" @default.
- W765497804 abstract "Akt2 is a pivotal player in a complex web of signaling pathways controlling cell growth, proliferation, and survival. The deregulation or aberrations of Akt2 have been associated with tumor progression, metastatic spread, and, lastly, chemoresistance. The impairment of its activity has gained more attention because Akt2 is intertwined with a range of signaling paths, including the Phosphatidylinositol 3 kinase/Akt/Mammalian target of rapamycin (PI3K/mTOR) signaling axis, which are involved in macromolecules synthesis and metabolism. Here, we focus on Akt2 because of its involvement in the acquisition of stem cell-like properties, responsible for invasiveness and chemoresistance, also promoted by Twist. We also suggest therapeutic strategies targeting Akt2 to overcome the drawbacks of current cancer therapies." @default.
- W765497804 created "2016-06-24" @default.
- W765497804 creator A5003571753 @default.
- W765497804 creator A5013021651 @default.
- W765497804 creator A5053692453 @default.
- W765497804 creator A5058511714 @default.
- W765497804 date "2015-09-01" @default.
- W765497804 modified "2023-10-18" @default.
- W765497804 title "Implications of Akt2/Twist crosstalk on breast cancer metastatic outcome" @default.
- W765497804 cites W1523439243 @default.
- W765497804 cites W1529336528 @default.
- W765497804 cites W1970265228 @default.
- W765497804 cites W1974504182 @default.
- W765497804 cites W1981711832 @default.
- W765497804 cites W1984621921 @default.
- W765497804 cites W1985719168 @default.
- W765497804 cites W1993253909 @default.
- W765497804 cites W1995646637 @default.
- W765497804 cites W1997316363 @default.
- W765497804 cites W2012830649 @default.
- W765497804 cites W2014622924 @default.
- W765497804 cites W2017333359 @default.
- W765497804 cites W2018207073 @default.
- W765497804 cites W2023753181 @default.
- W765497804 cites W2026842712 @default.
- W765497804 cites W2045713322 @default.
- W765497804 cites W2047401805 @default.
- W765497804 cites W2048519468 @default.
- W765497804 cites W2051940224 @default.
- W765497804 cites W2054564351 @default.
- W765497804 cites W2058088175 @default.
- W765497804 cites W2058645214 @default.
- W765497804 cites W2058720172 @default.
- W765497804 cites W2061180610 @default.
- W765497804 cites W2064592094 @default.
- W765497804 cites W2068912983 @default.
- W765497804 cites W2069308912 @default.
- W765497804 cites W2074420260 @default.
- W765497804 cites W2091000595 @default.
- W765497804 cites W2093829133 @default.
- W765497804 cites W2094079572 @default.
- W765497804 cites W2094422309 @default.
- W765497804 cites W2098192935 @default.
- W765497804 cites W2108822416 @default.
- W765497804 cites W2111517537 @default.
- W765497804 cites W2115619132 @default.
- W765497804 cites W2117497402 @default.
- W765497804 cites W2120026123 @default.
- W765497804 cites W2122860911 @default.
- W765497804 cites W2123467807 @default.
- W765497804 cites W2127063807 @default.
- W765497804 cites W2127480567 @default.
- W765497804 cites W2130315090 @default.
- W765497804 cites W2132319466 @default.
- W765497804 cites W2146414563 @default.
- W765497804 cites W2149818581 @default.
- W765497804 cites W2150026213 @default.
- W765497804 cites W2151714012 @default.
- W765497804 cites W2152965684 @default.
- W765497804 cites W2153174576 @default.
- W765497804 cites W2158294714 @default.
- W765497804 cites W2158489637 @default.
- W765497804 cites W2161655114 @default.
- W765497804 cites W2168032447 @default.
- W765497804 doi "https://doi.org/10.1016/j.drudis.2015.06.010" @default.
- W765497804 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26136161" @default.
- W765497804 hasPublicationYear "2015" @default.
- W765497804 type Work @default.
- W765497804 sameAs 765497804 @default.
- W765497804 citedByCount "28" @default.
- W765497804 countsByYear W7654978042015 @default.
- W765497804 countsByYear W7654978042016 @default.
- W765497804 countsByYear W7654978042017 @default.
- W765497804 countsByYear W7654978042018 @default.
- W765497804 countsByYear W7654978042019 @default.
- W765497804 countsByYear W7654978042020 @default.
- W765497804 countsByYear W7654978042021 @default.
- W765497804 countsByYear W7654978042022 @default.
- W765497804 countsByYear W7654978042023 @default.
- W765497804 crossrefType "journal-article" @default.
- W765497804 hasAuthorship W765497804A5003571753 @default.
- W765497804 hasAuthorship W765497804A5013021651 @default.
- W765497804 hasAuthorship W765497804A5053692453 @default.
- W765497804 hasAuthorship W765497804A5058511714 @default.
- W765497804 hasConcept C127413603 @default.
- W765497804 hasConcept C154137905 @default.
- W765497804 hasConcept C169822122 @default.
- W765497804 hasConcept C24326235 @default.
- W765497804 hasConcept C2777609662 @default.
- W765497804 hasConcept C502942594 @default.
- W765497804 hasConcept C55493867 @default.
- W765497804 hasConcept C60644358 @default.
- W765497804 hasConcept C62112901 @default.
- W765497804 hasConcept C62478195 @default.
- W765497804 hasConcept C71924100 @default.
- W765497804 hasConcept C75217442 @default.
- W765497804 hasConcept C86554907 @default.
- W765497804 hasConcept C86803240 @default.