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- W765562018 abstract "Introduction Respiratory infection etiology correlates with many factors and can influence long-term prognosis in cystic fibrosis patients. Our objective was to correlate bacteria isolated from sputum with clinical and epidemiological characteristics. Methods Bacterial, epidemiological and clinical data from 33 cystic fibrosis patients followed between July 2011 and June 2014 were analyzed. Results Of the 296 respiratory cultures analyzed, 165 were from patients with clinical respiratory exacerbation and in this group there were no difference from previous agents in 97 cultures (in 13 cases, microbiological investigation was negative). MSSA and H. influenzae were the main bacteria in children less than 5 years old, MSSA, H. influenzae and Enterobacteriaceae in age 5 to 10 and MSSA and P. aeruginosa in patients older than 10. In the 182 cultures related to patients with chronic infection, 61.5% had respiratory symptoms. MSSA was the main bacteria responsible for chronic infection in patients older than 5 years (67.3% in 5 to 10-year-old and 47.7% for older than 10), with P. aeruginosa being the second most common from patients older than 10 years (19.5%). MSSA was also the main chronic infection bacteria in female and deltaF508 homozygote patients, while male non-deltaF508 heterozygote patients had chronic infection mainly by P. aeruginosa . Conclusion Respiratory exacerbations can have multifactorial etiologies and bacteria are not always isolated. Acute and chronic infection etiology varies with age. Chronic infection prevalence, but also specific bacteria can be related to gender and genotype." @default.
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- W765562018 date "2015-06-01" @default.
- W765562018 modified "2023-10-17" @default.
- W765562018 title "42 Microbiologic bacterial agents in a young cystic fibrosis population" @default.
- W765562018 doi "https://doi.org/10.1016/s1569-1993(15)30219-8" @default.
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