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- W765608368 abstract "The present study was conducted to explore the anti-inflammatory action of (HPS) purified from Cumin (Cuminum cymium L.) seed against periodontitis. From the study in which human leukocyte was employed to detect the inhibiting effects of 5-lipokygenase and cyclooxygenase, enzymes generating carriers of infection like and PGs, as well as of collagenase and elastase, organ-destroying enzymes, following conclusions could be drawn: HPS was found to inhibit leukotrien biosynthesis by stimulating more than 97% of human polymorphonuclear leukocyte (PMNL) with addition of when was set at . Ninety-two percent of enzyme activation turned out to be inhibited when was added in a test to prove inhibiting effects of HPS against activation of PMNL 5-lipoxygenase from homogeneous humans and purified 5-lipoxygenase on the market. Besides, for enzyme activation was valued at , while the value of for purified 5-lipoxygenase was . The values of COX-activated leukocyte and purified collagenase were and , respectively. Moreover, the value of for activation of leukocyte collagenase was , whereas that for purified collagenase was . In case of leukocyte elastase, addition of inhibited its activation by 66%. In case of purified one, however, activation of enzyme was inhibited by 25% with addition of . Furthermore, the value for activation of leukocyte elastase was revealed to be . From the virulence test with human gingiva cell, it was shown that, on the second day of cultivation, 47.83% of the cell had been activated when HPS was added by . Even the addition of HPS by featured 68.53% of cell activation, suggesting relatively strong toxicity of the substance against gingiva cell." @default.
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- W765608368 date "2007-01-01" @default.
- W765608368 modified "2023-09-23" @default.
- W765608368 title "Enzymatic Assessment of $2-Hydroxyethyl-{beta}-undecenate$ Purified from Cumin (Cuminum cymium L.) Seed for Anti-periodontitis" @default.
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