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• W765620171 abstract "Research Article16 September 1996free access Effects on differentiation by the promyelocytic leukemia PML/RARalpha protein depend on the fusion of the PML protein dimerization and RARalpha DNA binding domains. F. Grignani F. Grignani Istituto di Clinica Medica I, Policlinico Monteluce, Perugia University, Italy. Search for more papers by this author U. Testa U. Testa Istituto di Clinica Medica I, Policlinico Monteluce, Perugia University, Italy. Search for more papers by this author D. Rogaia D. Rogaia Istituto di Clinica Medica I, Policlinico Monteluce, Perugia University, Italy. Search for more papers by this author P. F. Ferrucci P. F. Ferrucci Istituto di Clinica Medica I, Policlinico Monteluce, Perugia University, Italy. Search for more papers by this author P. Samoggia P. Samoggia Istituto di Clinica Medica I, Policlinico Monteluce, Perugia University, Italy. Search for more papers by this author A. Pinto A. Pinto Istituto di Clinica Medica I, Policlinico Monteluce, Perugia University, Italy. Search for more papers by this author D. Aldinucci D. Aldinucci Istituto di Clinica Medica I, Policlinico Monteluce, Perugia University, Italy. Search for more papers by this author V. Gelmetti V. Gelmetti Istituto di Clinica Medica I, Policlinico Monteluce, Perugia University, Italy. Search for more papers by this author M. Fagioli M. Fagioli Istituto di Clinica Medica I, Policlinico Monteluce, Perugia University, Italy. Search for more papers by this author M. Alcalay M. Alcalay Istituto di Clinica Medica I, Policlinico Monteluce, Perugia University, Italy. Search for more papers by this author J. Seeler J. Seeler Istituto di Clinica Medica I, Policlinico Monteluce, Perugia University, Italy. Search for more papers by this author F. Grignani F. Grignani Istituto di Clinica Medica I, Policlinico Monteluce, Perugia University, Italy. Search for more papers by this author I. Nicoletti I. Nicoletti Istituto di Clinica Medica I, Policlinico Monteluce, Perugia University, Italy. Search for more papers by this author C. Peschle C. Peschle Istituto di Clinica Medica I, Policlinico Monteluce, Perugia University, Italy. Search for more papers by this author P. G. Pelicci P. G. Pelicci Istituto di Clinica Medica I, Policlinico Monteluce, Perugia University, Italy. Search for more papers by this author F. Grignani F. Grignani Istituto di Clinica Medica I, Policlinico Monteluce, Perugia University, Italy. Search for more papers by this author U. Testa U. Testa Istituto di Clinica Medica I, Policlinico Monteluce, Perugia University, Italy. Search for more papers by this author D. Rogaia D. Rogaia Istituto di Clinica Medica I, Policlinico Monteluce, Perugia University, Italy. Search for more papers by this author P. F. Ferrucci P. F. Ferrucci Istituto di Clinica Medica I, Policlinico Monteluce, Perugia University, Italy. Search for more papers by this author P. Samoggia P. Samoggia Istituto di Clinica Medica I, Policlinico Monteluce, Perugia University, Italy. Search for more papers by this author A. Pinto A. Pinto Istituto di Clinica Medica I, Policlinico Monteluce, Perugia University, Italy. Search for more papers by this author D. Aldinucci D. Aldinucci Istituto di Clinica Medica I, Policlinico Monteluce, Perugia University, Italy. Search for more papers by this author V. Gelmetti V. Gelmetti Istituto di Clinica Medica I, Policlinico Monteluce, Perugia University, Italy. Search for more papers by this author M. Fagioli M. Fagioli Istituto di Clinica Medica I, Policlinico Monteluce, Perugia University, Italy. Search for more papers by this author M. Alcalay M. Alcalay Istituto di Clinica Medica I, Policlinico Monteluce, Perugia University, Italy. Search for more papers by this author J. Seeler J. Seeler Istituto di Clinica Medica I, Policlinico Monteluce, Perugia University, Italy. Search for more papers by this author F. Grignani F. Grignani Istituto di Clinica Medica I, Policlinico Monteluce, Perugia University, Italy. Search for more papers by this author I. Nicoletti I. Nicoletti Istituto di Clinica Medica I, Policlinico Monteluce, Perugia University, Italy. Search for more papers by this author C. Peschle C. Peschle Istituto di Clinica Medica I, Policlinico Monteluce, Perugia University, Italy. Search for more papers by this author P. G. Pelicci P. G. Pelicci Istituto di Clinica Medica I, Policlinico Monteluce, Perugia University, Italy. Search for more papers by this author Author Information F. Grignani1, U. Testa1, D. Rogaia1, P. F. Ferrucci1, P. Samoggia1, A. Pinto1, D. Aldinucci1, V. Gelmetti1, M. Fagioli1, M. Alcalay1, J. Seeler1, F. Grignani1, I. Nicoletti1, C. Peschle1 and P. G. Pelicci1 1Istituto di Clinica Medica I, Policlinico Monteluce, Perugia University, Italy. The EMBO Journal (1996)15:4949-4958https://doi.org/10.1002/j.1460-2075.1996.tb00875.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info The block of terminal differentiation is a prominent feature of acute promyelocytic leukemia (APL) and its release by retinoic acid correlates with disease remission. Expression of the APL-specific PML/RARalpha fusion protein in hematopoietic precursor cell lines blocks terminal differentiation, suggesting that PML/ RARalpha may have the same activity in APL blasts. We expressed different PML/RARalpha mutants in U937 and TF-1 cells and demonstrated that the integrity of the PML protein dimerization and RARalpha DNA binding domains is crucial for the differentiation block induced by PML/RARalpha, and that these domains exert their functions only within the context of the fusion protein. Analysis of the in vivo dimerization and cell localization properties of the PML/RARalpha mutants revealed that PML/RARalpha–PML and PML/RARalpha–RXR heterodimers are not necessary for PML/RARalpha activity on differentiation. We propose that a crucial mechanism underlying PML/RARalpha oncogenic activity is the deregulation of a transcription factor, RARalpha, through its fusion with the dimerization interface of another nuclear protein, PML. Previous ArticleNext Article Volume 15Issue 181 September 1996In this issue RelatedDetailsLoading ..." @default.
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• W765620171 title "Effects on differentiation by the promyelocytic leukemia PML/RARalpha protein depend on the fusion of the PML protein dimerization and RARalpha DNA binding domains." @default.
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