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- W765695162 abstract "目的探讨细胞凋亡相关基因p53、bcl-2 mRNA表达与喉鳞癌发生、发展、临床病理及分期分型的关系。方法采用原位杂交技术(in situ hybridization)对60例喉鳞癌及8例声带息肉标本进行突变型p53、bcl-2 mRNA检测。结果 60例喉鳞癌中p53、bcl-2 mRNA阳性表达率分别为66.7%和48.3%，8例声带息肉全部为阴性，p53、bcl-2 mRNA表达与喉鳞癌分化程度及颈淋巴结转移有关，而与喉鳞癌的临床分期、分型无关。结论 p53、bcl-2基因可能参与了喉鳞癌细胞凋亡的调节，在喉鳞癌的发生、发展和凋亡抑制过程中可能起着重要的作用。" @default.
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- W765695162 date "2001-05-10" @default.
- W765695162 modified "2023-10-18" @default.
- W765695162 title "细胞凋亡相关基因p53、bcl-2 mRNA表达与喉鳞癌关系的研究" @default.
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