FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W7658283> ?p ?o ?g. }

• W7658283 endingPage "338" @default.
• W7658283 startingPage "317" @default.
• W7658283 abstract "Although the ability of IL-2 to induce sustained tumor regression in patients with renal cell cancer and melanoma established a clinical role for cytokine therapy in fighting cancer, the severe toxicity seen in early trials limited its application to a select group of patients (1). In 1989 cytotoxic lymphocyte maturation factor, later termed IL-12, was discovered (2). IL-12 plays a central role in interferon gamma (IFN-γ) production and the development of a Th1 type immune response, thereby playing a role in both innate and adaptive immunity. In mouse models, IL-12 can inhibit tumor growth and metastasis. Early clinical trials of rhIL-12 in melanoma and renal cell cancer were complicated by severe toxicity and attenuation of the immune response over time. Revised dosing schedules, alternate routes of administration, and the use of combination cytokine therapy have led to improved tolerability and more sustained immune activation, but have resulted in only modest clinical activity. Current clinical trials continue to explore new ways to augment the antitumor activity of IL-12 in lymphoma and other potentially responsive malignancies." @default.
• W7658283 created "2016-06-24" @default.
• W7658283 creator A5034112194 @default.
• W7658283 creator A5037211385 @default.
• W7658283 date "2007-01-01" @default.
• W7658283 modified "2023-09-23" @default.
• W7658283 title "Interleukin-12 and Cancer Therapy" @default.
• W7658283 cites W1498677439 @default.
• W7658283 cites W1517849046 @default.
• W7658283 cites W1521747187 @default.
• W7658283 cites W1525077036 @default.
• W7658283 cites W1537495156 @default.
• W7658283 cites W1546462873 @default.
• W7658283 cites W1546897419 @default.
• W7658283 cites W1561535731 @default.
• W7658283 cites W1586984865 @default.
• W7658283 cites W1607695063 @default.
• W7658283 cites W1617786219 @default.
• W7658283 cites W1642873092 @default.
• W7658283 cites W1644502582 @default.
• W7658283 cites W166636401 @default.
• W7658283 cites W1748261727 @default.
• W7658283 cites W1823669223 @default.
• W7658283 cites W1835281509 @default.
• W7658283 cites W1838853754 @default.
• W7658283 cites W186409735 @default.
• W7658283 cites W1930158525 @default.
• W7658283 cites W1934146346 @default.
• W7658283 cites W1953740866 @default.
• W7658283 cites W1957147460 @default.
• W7658283 cites W1964909764 @default.
• W7658283 cites W1965620380 @default.
• W7658283 cites W1975588465 @default.
• W7658283 cites W1977782275 @default.
• W7658283 cites W1977817262 @default.
• W7658283 cites W1978971257 @default.
• W7658283 cites W1985929162 @default.
• W7658283 cites W1985981664 @default.
• W7658283 cites W1986370046 @default.
• W7658283 cites W1992016699 @default.
• W7658283 cites W1995529916 @default.
• W7658283 cites W1996517462 @default.
• W7658283 cites W1997913769 @default.
• W7658283 cites W2006073656 @default.
• W7658283 cites W2008407604 @default.
• W7658283 cites W2010925210 @default.
• W7658283 cites W2012628280 @default.
• W7658283 cites W2016956768 @default.
• W7658283 cites W2027874358 @default.
• W7658283 cites W20286704 @default.
• W7658283 cites W2030411429 @default.
• W7658283 cites W2033545363 @default.
• W7658283 cites W2042094925 @default.
• W7658283 cites W2044325609 @default.
• W7658283 cites W2051316659 @default.
• W7658283 cites W2059119781 @default.
• W7658283 cites W2065134760 @default.
• W7658283 cites W2069929656 @default.
• W7658283 cites W2075853586 @default.
• W7658283 cites W2082946984 @default.
• W7658283 cites W2086770363 @default.
• W7658283 cites W2087905758 @default.
• W7658283 cites W2088639793 @default.
• W7658283 cites W2096810938 @default.
• W7658283 cites W2099034322 @default.
• W7658283 cites W2102156468 @default.
• W7658283 cites W2104439753 @default.
• W7658283 cites W2109506765 @default.
• W7658283 cites W2110826114 @default.
• W7658283 cites W2111544074 @default.
• W7658283 cites W2116641130 @default.
• W7658283 cites W2119986617 @default.
• W7658283 cites W2129154410 @default.
• W7658283 cites W2134472621 @default.
• W7658283 cites W2149579127 @default.
• W7658283 cites W2151707711 @default.
• W7658283 cites W2158361318 @default.
• W7658283 cites W2159133324 @default.
• W7658283 cites W2159520551 @default.
• W7658283 cites W2161122282 @default.
• W7658283 cites W2163796754 @default.
• W7658283 cites W2163856919 @default.
• W7658283 cites W2165588484 @default.
• W7658283 cites W2167711236 @default.
• W7658283 cites W2330547546 @default.
• W7658283 cites W2407573313 @default.
• W7658283 cites W4313316454 @default.
• W7658283 cites W4313347782 @default.
• W7658283 doi "https://doi.org/10.1007/978-1-59745-455-1_18" @default.
• W7658283 hasPublicationYear "2007" @default.
• W7658283 type Work @default.
• W7658283 sameAs 7658283 @default.
• W7658283 citedByCount "1" @default.
• W7658283 countsByYear W76582832018 @default.
• W7658283 crossrefType "book-chapter" @default.
• W7658283 hasAuthorship W7658283A5034112194 @default.
• W7658283 hasAuthorship W7658283A5037211385 @default.
• W7658283 hasConcept C121608353 @default.

• next