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• W765894866 abstract "The monoterpene β-myrcene is widely used in cosmetics, food and beverages, and it is normally found in the essential oils of Citrus fruits, such as Citrus aurantium. The aim of this study was to determine the antisecretory activity of β-myrcene, determine its mechanism of action and assess the effect of this monoterpene in experimental gastroesophageal reflux assay. Male wistar rats (180-220 g) or male swiss mice (25-30g) were used to generate the following models: pyloric ligation-induced ulcers and the evaluation of gastric acid secretion stimulated by secretagogues; Katp channels and the involvement of Ca channels; in vitro determination of H/K-ATPase enzymatic activity inhibition; gastroesophageal reflux induced by esophagitis, lipid peroxidation (MDA) and gastrin measurement. Animals were treated with a positive control (lansoprazole (30mg/kg) or omeprazole (345μg/ml), vehicle (8% Tween 80®) or β-myrcene (7.5mg/kg). The results are expressed as the mean ± S.E.M. Statistical significance was determined by oneway analysis of variance followed by Dunnett’s or Tukey’s test. P-values<0.05 were considered to be statistically significant. The oral and intraduodenal administration of β-myrcene (9.11 ± 0.96 and 6.40 ± 0.24, respectively) reduced the H concentration compared to the vehicle (13.33 ± 1.23 and 19.20 ± 1.24 mEq/mL/4h, respectively). To verify the mechanisms responsible for this action, gastric acid secretion was stimulated by secretagogues: histamine, bethanechol or pentagastrin. β-myrcene was only active against pentagastrin, so gastrin was measured in the plasma. Thus, treatment with β-myrcene reduced gastrin secretion compared with the control group (10.89 ± 3.99) pmol/L. Furthermore, treatment with the Katp channel blocker, glibenclamide (5mg/kg), significantly reduced the gastroprotective effects of β-myrcene (39.80±5.30) mm and diazoxide (3mg/kg) (62.20±8.15) mm when compared to the groups pretreated with saline, indicating a role for Katp channels in gastroprotection. Moreover, β-myrcene displayed activity through the intraduodenal route at a dose of 7.5mg/kg, as it significantly decreased esophageal lesions (13,21±3,551) mm and decreased lipid peroxidation levels (5,332 ± 0,2352) nmol TBARS/mg protein compared to the vehicle group (141,0 ± 55,33 and 10,75 ± 1,558, respectively). Thus, this study indicates that β-myrcene displays important antisecretory activity modulated by the action of gastrin." @default.
• W765894866 created "2016-06-24" @default.
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• W765894866 date "2014-02-21" @default.
• W765894866 modified "2023-09-22" @default.
• W765894866 title "Elucidação dos mecanismos de ação do monoterpeno β-mirceno sobre as úlceras pépticas" @default.
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