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- W765901730 abstract "目的:通过侧脑室注射5-HT(5-羟色胺,5-Hydroxytryptamine)类似物5,7-DHT(5,7-双羟色胺.5,7-dihydroxytryptamine),毁损中缝背核的5-HT能神经元,通过行为学评估研究其是否导致小鼠抑郁样症状,探讨5-HT在抑郁发病机制中的作用。方法:C57BL/6J小鼠经脑室注射5,7-DHT后14天,观察体重变化,并使用强制游泳实验、悬尾实验评估其是否出现抑郁症状,并用免疫组织化学方法观察中缝背核5-HT神经元的残存情况。结果:侧脑室中注射5,7-DHT后14天,脑中中缝背核的5-HT能神经元几乎完全消失,被GFAP阳性的星形胶质细胞所代替,小鼠体重几乎不增加、强制游泳实验和悬尾实验中的“无动时间”均明显延长,表现出明显的抑郁症状。结论:5,7-DHT可以毁损5-HT神经元,引起抑郁症状,提示5-HT在抑郁症的发病机制中发挥着-定作用。a" @default.
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- W765901730 date "2006-01-01" @default.
- W765901730 modified "2023-10-15" @default.
- W765901730 title "5,7-DHT诱导5-HT神经元毁损致小鼠抑郁表现" @default.
- W765901730 hasPublicationYear "2006" @default.
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