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• W76602793 abstract "Research Article1 June 1995free access Secretion by Trypanosoma cruzi of a peptidyl-prolyl cis-trans isomerase involved in cell infection. A. Moro A. Moro Instituto de Parasitología y Biomedicina, CSIC, Granada, Spain. Search for more papers by this author F. Ruiz-Cabello F. Ruiz-Cabello Instituto de Parasitología y Biomedicina, CSIC, Granada, Spain. Search for more papers by this author A. Fernández-Cano A. Fernández-Cano Instituto de Parasitología y Biomedicina, CSIC, Granada, Spain. Search for more papers by this author R.P. Stock R.P. Stock Instituto de Parasitología y Biomedicina, CSIC, Granada, Spain. Search for more papers by this author A. González A. González Instituto de Parasitología y Biomedicina, CSIC, Granada, Spain. Search for more papers by this author A. Moro A. Moro Instituto de Parasitología y Biomedicina, CSIC, Granada, Spain. Search for more papers by this author F. Ruiz-Cabello F. Ruiz-Cabello Instituto de Parasitología y Biomedicina, CSIC, Granada, Spain. Search for more papers by this author A. Fernández-Cano A. Fernández-Cano Instituto de Parasitología y Biomedicina, CSIC, Granada, Spain. Search for more papers by this author R.P. Stock R.P. Stock Instituto de Parasitología y Biomedicina, CSIC, Granada, Spain. Search for more papers by this author A. González A. González Instituto de Parasitología y Biomedicina, CSIC, Granada, Spain. Search for more papers by this author Author Information A. Moro1, F. Ruiz-Cabello1, A. Fernández-Cano1, R.P. Stock1 and A. González1 1Instituto de Parasitología y Biomedicina, CSIC, Granada, Spain. The EMBO Journal (1995)14:2483-2490https://doi.org/10.1002/j.1460-2075.1995.tb07245.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info Macrophage infectivity potentiators are membrane proteins described as virulence factors in bacterial intracellular parasites, such as Legionella and Chlamydia. These factors share amino acid homology to eukaryotic peptidyl-prolyl cis-trans isomerases that are inhibited by FK506, an inhibitor of signal transduction in mammalian cells with potent immunosuppressor activity. We report here the characterization of a protein released into the culture medium by the infective stage of the protozoan intracellular parasite Trypanosoma cruzi. The protein possesses a peptidyl-prolyl cis-trans isomerase activity that is inhibited by FK506 and its non-immunosuppressing derivative L-685,818. The corresponding gene presents sequence homology with bacterial macrophage infectivity potentiators. The addition of the protein, produced heterologously in Escherichia coli, to cultures of trypomastigotes and simian epithelial or HeLa cells enhances invasion of the mammalian cells by the parasites. Antibodies raised in mice against the T.cruzi isomerase greatly reduce infectivity. A similar reduction of infectivity is obtained by addition to the cultures of FK506 and L-685,818. We concluded that the T.cruzi isomerase is involved in cell invasion. Previous ArticleNext Article Volume 14Issue 111 June 1995In this issue RelatedDetailsLoading ..." @default.
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• W76602793 title "Secretion by Trypanosoma cruzi of a peptidyl-prolyl cis-trans isomerase involved in cell infection." @default.
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