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Matches in SemOpenAlex for { <https://semopenalex.org/work/W766222058> ?p ?o ?g. }

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• W766222058 abstract "A series of new 2′-deoxy-2′-β-fluoro-4′-azido-β-d-arabinofuranosyl cytidine derivatives bearing heteroatom-containing N4-substituents were designed and synthesized. Antiviral screening in HepG2.2.15 cells identified three analogs (1a, 1d & 1g) with good anti-HBV activity and low cytotoxicty. Of them, compound 1g exhibited significant inhibitory activity on both HBV antigens secretion (EC50, HBsAg = 9 nM, EC50, HBeAg = 0.25 μM) and viral DNA replication (intracellular, EC50 = 0.099 μM; extracellular, EC50 < 0.01 μM)." @default.
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• W766222058 date "2015-08-01" @default.
• W766222058 modified "2023-10-14" @default.
• W766222058 title "Design, synthesis, and biological evaluation of new N 4 -Substituted 2′-deoxy-2′-fluoro-4′-azido cytidine derivatives as potent anti-HBV agents" @default.
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• W766222058 doi "https://doi.org/10.1016/j.ejmech.2015.06.030" @default.
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