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• W76629885 startingPage "111" @default.
• W76629885 abstract "This chapter presents a summarization of some of the current knowledge about the mechanisms by which cellular calcium (Ca2+) is regulated by agonists acting through the phosphoinositide system. The initial, agonist-induced [Ca2+]i signal in such cells is derived from the Ca2+ releasing actions of (1,4,5)IP3 on at least one specific intracellular Ca2+-sequestering organelle. However, it is also likely that this process may be regulated, either by metabolites of (1,4,5)IP3, such as (1,3,4,5)IP4, or by other second messenger systems. In virtually all cells that utilize this mechanism, the initial release of intracellular Ca2+ is followed or accompanied by an accelerated entry of Ca2+ into the cytoplasm across the plasma membrane. The mechanism by which this process is regulated has been somewhat more elusive and may vary in different cellular systems. There is strong evidence that in some cell types the depletion of the agonist-sensitive intracellular Ca2+ store by (1,4,5)IP3 or possibly (1,4,5)IP3 and (1,3,4,5)IP4 generates a secondary signal of unknown nature that activates Ca2+ entry. The investigation of this and other interesting aspects of the Ca2+-phosphoinositide system would provide with many additional discoveries and surprises in the near future." @default.
• W76629885 created "2016-06-24" @default.
• W76629885 creator A5060890309 @default.
• W76629885 date "1990-01-01" @default.
• W76629885 modified "2023-09-27" @default.
• W76629885 title "The Integration of Receptor-Regulated Intracellular Calcium Release and Calcium Entry across the Plasma Membrane" @default.
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• W76629885 doi "https://doi.org/10.1016/b978-0-12-152831-7.50004-4" @default.
• W76629885 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1978823" @default.
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