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- W766306784 abstract "Xue-Zhi-Ning (XZN) is a traditional Chinese medicine formula, containing active ingredients with poor solubility in water, which has been demonstrated to be helpful for patients with hyperlipidemia. One-pot β-cyclodextrin (β-CD)-assisted extraction of active ingredients from XZN has been carried out to develop an efficient and eco-friendly extraction process. Five active compounds--rubrofusarin gentiobioside, 2,3,5,4'-tetrahydroxy-stilbene-2-O-β-D-glucoside, emodin, nuciferine and quercetin--were identified by UPLC/DAD/MS and used as indexes to evaluate the process optimized by an orthogonal test. The results showed that addition of β-CD significantly enhanced the extraction ratios of all five components. The enhancement of extraction ratios was positively correlated with the apparent formation constants between β-CD and the compounds. The study also showed that the stabilities and dissolution rates of the active ingredients were improved in the presence of β-CD. This one-pot β-cyclodextrin-assisted extraction has the potential to be applied in pharmaceutical preparations directly." @default.
- W766306784 created "2016-06-24" @default.
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- W766306784 date "2015-11-01" @default.
- W766306784 modified "2023-09-30" @default.
- W766306784 title "One-pot β-cyclodextrin-assisted extraction of active ingredients from Xue–Zhi–Ning basing its encapsulated ability" @default.
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- W766306784 doi "https://doi.org/10.1016/j.carbpol.2015.06.072" @default.
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