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- W7663529 startingPage "205" @default.
- W7663529 abstract "Heat shock protein 70 (Hsp70) is a powerful chaperone whose expression is induced in response to a wide variety of physiological and environmental insults, including anticancer chemotherapy, thus allowing the cell to survive to lethal conditions. Hsp70 cytoprotective properties may be explained by its anti-apoptotic function. Indeed, this protein can inhibit key effectors of the apoptotic machinery at the pre- and postmitochondrial level. In cancer cells, the expression of Hsp70 is abnormally high, and Hsp70 may participate in oncogenesis and in resistance to chemotherapy. In rodent models, Hsp70 overexpression increases tumor growth and metastatic potential. Depletion or inhibition of Hsp70 frequently reduces the size of the tumors and even can cause their complete involution. But Hsp70 can also be found in the extracellular medium. Its role is then immunogenic and the term chaperokine to define the extracellular chaperones has been advanced. Hsp70 tumorigenic functions as well as the strategies that are being developed in cancer therapy in order to inhibit Hsp70 are commented in this chapter." @default.
- W7663529 created "2016-06-24" @default.
- W7663529 creator A5019788838 @default.
- W7663529 creator A5064514391 @default.
- W7663529 creator A5086891968 @default.
- W7663529 date "2011-01-01" @default.
- W7663529 modified "2023-10-15" @default.
- W7663529 title "Hsp70: Anti-apoptotic and Tumorigenic Protein" @default.
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