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- W766402206 abstract "For over a century it has been known that CO2 has profound effects on the level of ventilation and that minute ventilation is exquisitely sensitive to changes in partial pressure of CO2 (PCO2). It is also known that effects of CO2 on ventilation are primarily through changes in hydrogen ion concentration [H+] in the brain. Several areas of chemosensitivity have been identified in the midbrain, particularly on the ventral surface of the medulla (VMS) that are essential in generating the neural output in response to changes in [H+] (Schlaefke et al, 1970; Burton and Kazemi, 2000; Kazemi and Johnson 2002). How the CO2/H+ signal is transduced centrally has been the subject of great interest and suggestions have included (i) H+ receptors, (ii) H+ gradient across neural membranes, (iii) altering ion channels and (iv) neurotransmitter release or activation." @default.
- W766402206 created "2016-06-24" @default.
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- W766402206 date "2003-01-01" @default.
- W766402206 modified "2023-09-27" @default.
- W766402206 title "C02/H+Signal Transduction and Central Ventilatory Control" @default.
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- W766402206 doi "https://doi.org/10.1007/978-1-4419-9280-2_51" @default.
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