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• W76657404 abstract "Innovations in healthcare delivery and Pharma require re-examination of process models at the foundation of our knowledge discovery and clinical practice. Despite real-time availability of ‘big data’ from ubiquitous sensors, mobile devices, 3D printing of drugs, and a mind shift in data ownership, data integration still remains one of the core challenges to innovation. Increasingly persistent, semantic data integration is gaining recognition for its dynamic data model and formalisms which make it possible to infer from and reason over interconnected contextualized data, creating actionable knowledge faster and at lower cost. While such technical advances underpin the successful strategies to drive positive patient outcomes or accelerate drug design, there are equally profound social changes towards the willingness of patients to share their own data - opening doors to new patient-centric, precision-medicine healthcare models. Adding astronomically rising costs in research and healthcare, we have arrived at a critical turning point where it is now well within our reach to change how drugs are developed, how trials are performed and how patients are treated - and we can do this with huge benefits for otherwise unsustainable industries. Examples show that not only is this possible today, but that such approaches already have traction; (i) in Pharma for assessing impact of excipient on drug stability and efficacy; for pre-clinical toxicity assessment and integral systems views on drug safety, (ii) in Government at the FDA’s cross species biomarker initiative to reduce animal testing and (iii) in Health Care for organ transplant rejection assessment and COPD. Using comparative effectiveness and side effect analyses to base treatments on solid prognoses and therapy decision support, we can and must change discovery and healthcare into a data driven and patient centric paradigm. The socio-economic benefits of such a change will be enormous." @default.
• W76657404 created "2016-06-24" @default.
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• W76657404 date "2013-01-01" @default.
• W76657404 modified "2023-09-25" @default.
• W76657404 title "Changing the Model in Pharma and Healthcare – Can We Afford to Wait Any Longer?" @default.
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• W76657404 doi "https://doi.org/10.1007/978-3-642-39437-9_1" @default.
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