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• W767574118 abstract "Recent advances in molecular genetics techniques have made dense marker maps available, and the prediction of breeding value at the genome level has been employed in genetics research. However, an increasingly large number of markers raise both statistical and computational issues in genomic selection (GS), and many methods have been developed for genomic prediction to address these problems, including ridge regression-best linear unbiased prediction (RR-BLUP), genomic best linear unbiased prediction, BayesA, BayesB, BayesCπ, and Bayesian LASSO. In this paper, these methods were compared regarding inference under different conditions, using real data from a wheat data set and simulated scenarios with a small number of quantitative trait loci (QTL) (20), a moderate number of QTL (60, 180) and an extreme number of QTL (540). This study showed that the genetic architecture of a trait should be fully considered when a GS method is chosen. If a small amount of loci had a large effect on a trait, great differences were found between the predictive ability of various methods and BayesCπ was recommended. Although there was almost no significant difference between the predictive ability of BayesCπ and BayesB, BayesCπ is more feasible than BayesB for real data analysis. If a trait was controlled by a moderate number of genes, the absolute differences between the various methods were small, but BayesA was also found to be the most accurate method. Furthermore, BayesA was widely adaptable and could perform well with different numbers of QTL. If a trait was controlled by an extreme number of minor genes, almost no significant differences were detected between the predictive ability of various methods, but RR-BLUP slightly outperformed the others in both simulated scenarios and real data analysis, thus demonstrating its robustness and indicating that it was quite effective in this case." @default.
• W767574118 created "2016-06-24" @default.
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• W767574118 date "2015-05-01" @default.
• W767574118 modified "2023-10-06" @default.
• W767574118 title "A comparison of genomic selection methods for breeding value prediction" @default.
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• W767574118 doi "https://doi.org/10.1007/s11434-015-0791-2" @default.
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