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• W767596352 abstract "ix CHAPTER 1: INTRODUCTION 1 1.1 Cancer 1 1.2 Breast cancer 2 1.3 Autophagy 4 1.4 Apoptosis 7 1.5 Bcl-2:Beclin-1 interaction regulates autophagy 9 1.6 Previous studies 11 1.7 Hypothesis 11 CHAPTER 2: MATERIALS AND METHODS 12 2.1 Cell lines and cell culture 12 2.2 Plasmid construction and virus infection 12 2.3 Cell viability and clonogenic survival 13 2.4 Detection and quantification of autophagic cells 14 v 2.5 Immunoprecipitation and Western blot analyses 15 2.6 Statistical analysis 16 CHAPTER 3: RESULTS 16 SECTION 1: Radiation induced cytoprotective autophagy in MCF-7 cell .... 16 3.1.1 Silencing of Beclin-1 inhibited autophagy and increased sensitivity in MCF-7 cell in response to radiation 16 3.1.2 The interaction between Beclin-1 and the anti-apoptotic Bcl-2 proteins in MCF-7 cells 23 3.1.3 Silencing of Bcl-2 enhanced the level of radiation-induced autophagy in MCF-7 cell 25 3.1.4 Enhancement of autophagy by Bcl-2 silencing increased growth inhibition effects produced by radiation in MCF-7 cell 29 SECTION 2: Radiation induced non-protective autophagy in Hs578t cell .. 32 3.2.1 Silencing of Beclin-1 inhibited radiation-induced autophagy in Hs578t cell 32 3.2.2 The expression levels of autophagy-related proteins in MCF-7 and Hs578t cells 38 3.2.3 The interaction between Beclin-1 and the exogenous Bcl-2 in Hs578t cell 40 3.2.4 Introduction of Bcl-2 inhibited radiation-induced autophagy in Hs578t cell 42 vi 3.2.5 Inhibition of autophagy by exogenous expression of Bcl-2 produced minimum changes in growth inhibition effects produced by radiation in Hs578t cells 47 SECTION 4: Discussion 51 SECTION 5: Future studies 53 References 54 VITA 60" @default.
• W767596352 created "2016-06-24" @default.
• W767596352 creator A5067224665 @default.
• W767596352 date "2014-01-01" @default.
• W767596352 modified "2023-09-23" @default.
• W767596352 title "THE ROLE OF CYTOPROTECTIVE AND NON-PROTECTIVE AUTOPHAGY IN RADIATION SENSITIVITY IN BREAST TUMOR CELLS" @default.
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• W767596352 doi "https://doi.org/10.25772/0j0r-sv98" @default.
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