Matches in SemOpenAlex for { <https://semopenalex.org/work/W76787411> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W76787411 endingPage "42" @default.
- W76787411 startingPage "35" @default.
- W76787411 abstract "Hammerhead ribozymes are effective modulators of gene expression due to their simple structure, site-specific cleavage activity and catalytic potential. The K-ras oncogene is thought to play an important role in the growth of pancreatic cancer, because an activated (mutated) ras gene is found in approximately 90% of human pancreatic cancers. In this study, we designed a hammerhead ribozyme directed against K-ras mRNA at codon 25 [K-ras Rz (25)], and investigated its efficacy in a cultured human pancreatic carcinoma cell line, MIA PaCa-2. K-ras Rz (25) significantly reduced the cellular K-ras mRNA level when introduced into the MIA PaCa-2 cells. The ribozyme suppressed cell growth. K-ras Rz (25) appears capable of reversing the malignant phenotype in human pancreatic carcinoma cells." @default.
- W76787411 created "2016-06-24" @default.
- W76787411 creator A5001002762 @default.
- W76787411 creator A5011371784 @default.
- W76787411 creator A5019146200 @default.
- W76787411 creator A5026636247 @default.
- W76787411 creator A5033618331 @default.
- W76787411 creator A5042950415 @default.
- W76787411 creator A5047427658 @default.
- W76787411 creator A5071904163 @default.
- W76787411 date "2004-06-01" @default.
- W76787411 modified "2023-09-23" @default.
- W76787411 title "An anti-K-ras ribozyme suppresses oncogene expression and cell growth of human pancreatic cancer." @default.
- W76787411 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15473338" @default.
- W76787411 hasPublicationYear "2004" @default.
- W76787411 type Work @default.
- W76787411 sameAs 76787411 @default.
- W76787411 citedByCount "1" @default.
- W76787411 crossrefType "journal-article" @default.
- W76787411 hasAuthorship W76787411A5001002762 @default.
- W76787411 hasAuthorship W76787411A5011371784 @default.
- W76787411 hasAuthorship W76787411A5019146200 @default.
- W76787411 hasAuthorship W76787411A5026636247 @default.
- W76787411 hasAuthorship W76787411A5033618331 @default.
- W76787411 hasAuthorship W76787411A5042950415 @default.
- W76787411 hasAuthorship W76787411A5047427658 @default.
- W76787411 hasAuthorship W76787411A5071904163 @default.
- W76787411 hasConcept C104317684 @default.
- W76787411 hasConcept C105580179 @default.
- W76787411 hasConcept C121608353 @default.
- W76787411 hasConcept C126322002 @default.
- W76787411 hasConcept C151730666 @default.
- W76787411 hasConcept C153911025 @default.
- W76787411 hasConcept C175156509 @default.
- W76787411 hasConcept C2779792011 @default.
- W76787411 hasConcept C2780210213 @default.
- W76787411 hasConcept C2781018059 @default.
- W76787411 hasConcept C29537977 @default.
- W76787411 hasConcept C43369102 @default.
- W76787411 hasConcept C502942594 @default.
- W76787411 hasConcept C54355233 @default.
- W76787411 hasConcept C62112901 @default.
- W76787411 hasConcept C67705224 @default.
- W76787411 hasConcept C71924100 @default.
- W76787411 hasConcept C76346623 @default.
- W76787411 hasConcept C81885089 @default.
- W76787411 hasConcept C86803240 @default.
- W76787411 hasConceptScore W76787411C104317684 @default.
- W76787411 hasConceptScore W76787411C105580179 @default.
- W76787411 hasConceptScore W76787411C121608353 @default.
- W76787411 hasConceptScore W76787411C126322002 @default.
- W76787411 hasConceptScore W76787411C151730666 @default.
- W76787411 hasConceptScore W76787411C153911025 @default.
- W76787411 hasConceptScore W76787411C175156509 @default.
- W76787411 hasConceptScore W76787411C2779792011 @default.
- W76787411 hasConceptScore W76787411C2780210213 @default.
- W76787411 hasConceptScore W76787411C2781018059 @default.
- W76787411 hasConceptScore W76787411C29537977 @default.
- W76787411 hasConceptScore W76787411C43369102 @default.
- W76787411 hasConceptScore W76787411C502942594 @default.
- W76787411 hasConceptScore W76787411C54355233 @default.
- W76787411 hasConceptScore W76787411C62112901 @default.
- W76787411 hasConceptScore W76787411C67705224 @default.
- W76787411 hasConceptScore W76787411C71924100 @default.
- W76787411 hasConceptScore W76787411C76346623 @default.
- W76787411 hasConceptScore W76787411C81885089 @default.
- W76787411 hasConceptScore W76787411C86803240 @default.
- W76787411 hasIssue "2" @default.
- W76787411 hasLocation W767874111 @default.
- W76787411 hasOpenAccess W76787411 @default.
- W76787411 hasPrimaryLocation W767874111 @default.
- W76787411 hasRelatedWork W1999398674 @default.
- W76787411 hasRelatedWork W2006162544 @default.
- W76787411 hasRelatedWork W2014956197 @default.
- W76787411 hasRelatedWork W2018124880 @default.
- W76787411 hasRelatedWork W2020236655 @default.
- W76787411 hasRelatedWork W2054236546 @default.
- W76787411 hasRelatedWork W2347552518 @default.
- W76787411 hasRelatedWork W2368160418 @default.
- W76787411 hasRelatedWork W2393680366 @default.
- W76787411 hasRelatedWork W76787411 @default.
- W76787411 hasVolume "29" @default.
- W76787411 isParatext "false" @default.
- W76787411 isRetracted "false" @default.
- W76787411 magId "76787411" @default.
- W76787411 workType "article" @default.