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- W768337726 abstract "The characteristic feature of healthy living organisms is the preservation of homeostasis. Compelling evidence highlight that the DNA damage response and repair (DDR/R) and immune response (ImmR) signaling networks work together favoring the harmonized function of (multi)cellular organisms. DNA and RNA viruses activate the DDR/R machinery in the host cells both directly and indirectly. Activation of DDR/R in turn favors the immunogenicity of the incipient cell. Hence, stimulation of DDR/R by exogenous or endogenous insults triggers innate and adaptive ImmR. The immunogenic properties of ionizing radiation, a prototypic DDR/R inducer, serve as suitable examples of how DDR/R stimulation alerts host immunity. Thus, critical cellular danger signals stimulate defense at the systemic level and vice versa. Disruption of DDR/R–ImmR cross talk compromises (multi)cellular integrity, leading to cell-cycle-related and immune defects. The emerging DDR/R–ImmR concept opens up a new avenue of therapeutic options, recalling the Hippocrates quote “everything in excess is opposed by nature.”" @default.
- W768337726 created "2016-06-24" @default.
- W768337726 creator A5016235730 @default.
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- W768337726 date "2015-10-01" @default.
- W768337726 modified "2023-09-26" @default.
- W768337726 title "The DNA damage response and immune signaling alliance: Is it good or bad? Nature decides when and where" @default.
- W768337726 cites W1487101581 @default.
- W768337726 cites W1507275598 @default.
- W768337726 cites W151635657 @default.
- W768337726 cites W1538419182 @default.
- W768337726 cites W1548587525 @default.
- W768337726 cites W1549679997 @default.
- W768337726 cites W1590320758 @default.
- W768337726 cites W1614344254 @default.
- W768337726 cites W1628408467 @default.
- W768337726 cites W1845637086 @default.
- W768337726 cites W1853088825 @default.
- W768337726 cites W1887076159 @default.
- W768337726 cites W1888665141 @default.
- W768337726 cites W1896868877 @default.
- W768337726 cites W1897129911 @default.
- W768337726 cites W1903606388 @default.
- W768337726 cites W1954041220 @default.
- W768337726 cites W1963588416 @default.
- W768337726 cites W1963731169 @default.
- W768337726 cites W1963774361 @default.
- W768337726 cites W1964659850 @default.
- W768337726 cites W1965037168 @default.
- W768337726 cites W1965038309 @default.
- W768337726 cites W1966994527 @default.
- W768337726 cites W1967034968 @default.
- W768337726 cites W1967060514 @default.
- W768337726 cites W1967229707 @default.
- W768337726 cites W1968807936 @default.
- W768337726 cites W1969464492 @default.
- W768337726 cites W1969845834 @default.
- W768337726 cites W1969888906 @default.
- W768337726 cites W1970227011 @default.
- W768337726 cites W1970679935 @default.
- W768337726 cites W1970924670 @default.
- W768337726 cites W1973300568 @default.
- W768337726 cites W1974070734 @default.
- W768337726 cites W1974248332 @default.
- W768337726 cites W1975275391 @default.
- W768337726 cites W1975280933 @default.
- W768337726 cites W1975368252 @default.
- W768337726 cites W1976495891 @default.
- W768337726 cites W1977800604 @default.
- W768337726 cites W1978425182 @default.
- W768337726 cites W1978782811 @default.
- W768337726 cites W1979891329 @default.
- W768337726 cites W1981033124 @default.
- W768337726 cites W1982047458 @default.
- W768337726 cites W1982415055 @default.
- W768337726 cites W1982481909 @default.
- W768337726 cites W1983262355 @default.
- W768337726 cites W1983487014 @default.
- W768337726 cites W1983517349 @default.
- W768337726 cites W1985585453 @default.
- W768337726 cites W1985786559 @default.
- W768337726 cites W1985830305 @default.
- W768337726 cites W1985859986 @default.
- W768337726 cites W1986689363 @default.
- W768337726 cites W1987213099 @default.
- W768337726 cites W1987448837 @default.
- W768337726 cites W1987912339 @default.
- W768337726 cites W1988388573 @default.
- W768337726 cites W1988924112 @default.
- W768337726 cites W1989551786 @default.
- W768337726 cites W1991221096 @default.
- W768337726 cites W1992819354 @default.
- W768337726 cites W1994389091 @default.
- W768337726 cites W1994826332 @default.
- W768337726 cites W1994905343 @default.
- W768337726 cites W1995588740 @default.
- W768337726 cites W1996315957 @default.
- W768337726 cites W1997028288 @default.
- W768337726 cites W1997069349 @default.
- W768337726 cites W1997893106 @default.
- W768337726 cites W1998032989 @default.
- W768337726 cites W1998876965 @default.
- W768337726 cites W1999177172 @default.
- W768337726 cites W1999912119 @default.
- W768337726 cites W1999982643 @default.
- W768337726 cites W2000177767 @default.
- W768337726 cites W2001235948 @default.
- W768337726 cites W2001720505 @default.
- W768337726 cites W2002934916 @default.
- W768337726 cites W2003623249 @default.
- W768337726 cites W2004273407 @default.
- W768337726 cites W2004763680 @default.