Matches in SemOpenAlex for { <https://semopenalex.org/work/W7686287> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W7686287 abstract "Exercise training (ExT) decreases mean arterial pressure (MAP) and heart rate (HR) in humans and in rat models of hypertension, but its effect on angiotensin II (Ang II)-dependent two kidney-one clip (2K-1C) hypertension has not been studied. Circulating Ang II acts upon circumventricular areas of the brain that project to paraventricular nucleus (PVN) whose efferent projections can influence baroreflex activity and sympathetic tone. We tested the hypothesis that six weeks of voluntary wheel ExT in 2K-1C rats would decrease MAP, HR and RSNA and that this effect is mediated via enhanced GABAergic and nitritergic mechanisms in the PVN. Awake, unrestrained sedentary (SED) or ExT sham and 2K-1C rats were studied before and after microinjection of 200 pmol bicuculline or 200 μg L-NAME into PVN. Resting MAP and HR was similar in sham ExT and SED rats, but MAP was lower in ExT vs SED 2K-1C rats (145 ± 4 vs 179 ± 11 mmHg, p < 0.05) as was HR. Bicuculline evoked roughly a two-fold greater rise in MAP, HR and RSNA in sham ExT vs SED rats (p < 0.05). In contrast, the rise in RSNA was attenuated in the ExT vs SED 2K-1C rats. The responses of the 2K-1C ExT rats most closely resembled those of the SED sham rats. Blockade of nitric oxide production did not alter responses in any of the groups. Thus, voluntary wheel ExT in sham clipped rats has a sympathoinhibitory effect mediated, at least in part, via GABAergic mechanisms in the PVN. In 2K-1C rats at a time when their elevated arterial pressure is Ang II dependent, ExT significantly decreases MAP and HR but these effects appear to be independent of GABA receptors in the PVN." @default.
- W7686287 created "2016-06-24" @default.
- W7686287 creator A5034185938 @default.
- W7686287 creator A5036646760 @default.
- W7686287 creator A5049375380 @default.
- W7686287 date "2007-01-01" @default.
- W7686287 modified "2023-10-16" @default.
- W7686287 title "Voluntary Wheel Exercise Training Decreases Arterial Pressure in Two Kidney‐One‐Clip Hypertensive Rats Independent of GABAergic Mechanisms in Paraventricular Nucleus" @default.
- W7686287 doi "https://doi.org/10.1096/fasebj.21.6.a932" @default.
- W7686287 hasPublicationYear "2007" @default.
- W7686287 type Work @default.
- W7686287 sameAs 7686287 @default.
- W7686287 citedByCount "0" @default.
- W7686287 crossrefType "journal-article" @default.
- W7686287 hasAuthorship W7686287A5034185938 @default.
- W7686287 hasAuthorship W7686287A5036646760 @default.
- W7686287 hasAuthorship W7686287A5049375380 @default.
- W7686287 hasConcept C126322002 @default.
- W7686287 hasConcept C126707884 @default.
- W7686287 hasConcept C134018914 @default.
- W7686287 hasConcept C168258287 @default.
- W7686287 hasConcept C170493617 @default.
- W7686287 hasConcept C17077164 @default.
- W7686287 hasConcept C191237925 @default.
- W7686287 hasConcept C2776452961 @default.
- W7686287 hasConcept C2776512019 @default.
- W7686287 hasConcept C2777953023 @default.
- W7686287 hasConcept C2779177108 @default.
- W7686287 hasConcept C2779263132 @default.
- W7686287 hasConcept C2780763569 @default.
- W7686287 hasConcept C2908929049 @default.
- W7686287 hasConcept C62525196 @default.
- W7686287 hasConcept C71924100 @default.
- W7686287 hasConcept C84393581 @default.
- W7686287 hasConceptScore W7686287C126322002 @default.
- W7686287 hasConceptScore W7686287C126707884 @default.
- W7686287 hasConceptScore W7686287C134018914 @default.
- W7686287 hasConceptScore W7686287C168258287 @default.
- W7686287 hasConceptScore W7686287C170493617 @default.
- W7686287 hasConceptScore W7686287C17077164 @default.
- W7686287 hasConceptScore W7686287C191237925 @default.
- W7686287 hasConceptScore W7686287C2776452961 @default.
- W7686287 hasConceptScore W7686287C2776512019 @default.
- W7686287 hasConceptScore W7686287C2777953023 @default.
- W7686287 hasConceptScore W7686287C2779177108 @default.
- W7686287 hasConceptScore W7686287C2779263132 @default.
- W7686287 hasConceptScore W7686287C2780763569 @default.
- W7686287 hasConceptScore W7686287C2908929049 @default.
- W7686287 hasConceptScore W7686287C62525196 @default.
- W7686287 hasConceptScore W7686287C71924100 @default.
- W7686287 hasConceptScore W7686287C84393581 @default.
- W7686287 hasIssue "6" @default.
- W7686287 hasLocation W76862871 @default.
- W7686287 hasOpenAccess W7686287 @default.
- W7686287 hasPrimaryLocation W76862871 @default.
- W7686287 hasRelatedWork W2010551395 @default.
- W7686287 hasRelatedWork W2069886130 @default.
- W7686287 hasRelatedWork W2108711978 @default.
- W7686287 hasRelatedWork W2110778161 @default.
- W7686287 hasRelatedWork W2129609331 @default.
- W7686287 hasRelatedWork W2141759820 @default.
- W7686287 hasRelatedWork W2144189646 @default.
- W7686287 hasRelatedWork W2150979289 @default.
- W7686287 hasRelatedWork W39773897 @default.
- W7686287 hasRelatedWork W7686287 @default.
- W7686287 hasVolume "21" @default.
- W7686287 isParatext "false" @default.
- W7686287 isRetracted "false" @default.
- W7686287 magId "7686287" @default.
- W7686287 workType "article" @default.