Matches in SemOpenAlex for { <https://semopenalex.org/work/W768744188> ?p ?o ?g. }
- W768744188 endingPage "46" @default.
- W768744188 startingPage "39" @default.
- W768744188 abstract "The aim of this work was to investigate if noradrenaline (NA), added in the coeliac ganglion -superior ovarian nerve- ovary system (CG-SON-O) and in ovary incubation, modifies the release of ovarian progesterone (P4), gonadotropin-releasing hormone (GnRH) and oestradiol (E2), and the expression of 3β-HSD and 20α-HSD and proapoptotic bax and antiapoptotic bcl-2 on dioestrus II in the rat. The CG-SON-O system and the ovary were removed and placed in one cuvette containing Krebs-Ringer solution (control groups), and NA was added to the ganglion compartment in the ex vivo system and in the ovary compartment in the ovary incubation (experimental groups). P4, GnRH and E2 were measured by RIA, and gene expression was measured by RT-PCR. In the ex-vivo system, the release of ovarian P4 and GnRH and the expression of 3β-HSD and bax decreased; E2 and bcl-2 increased, and the bax/bcl-2 ratio decreased. However, in the ovary incubation, P4, GnRH, the expression of 3β-HSD and bax increased; E2, the expression of 20α-HSD and bcl-2 decreased while the bax/bcl-2 ratio increased, thus favoring apoptosis. The peripheral nervous system protected the ovary from the apoptotic mechanisms while in the ovary incubation the effect was reverted. Our results indicate that NA regulates ovarian steroidogenesis and apoptosis by modulating GnRH release from the coeliac ganglion and ovary, being NA a possible generator of a GnRH-gonadotropins axis in the ovary. This work is expected to contribute with new evidence of the clinical importance of catecholamines and GnRH in therapy and prevention of ovarian pathologies." @default.
- W768744188 created "2016-06-24" @default.
- W768744188 creator A5051616848 @default.
- W768744188 creator A5059465515 @default.
- W768744188 creator A5059917897 @default.
- W768744188 creator A5068444870 @default.
- W768744188 creator A5073868405 @default.
- W768744188 creator A5087063713 @default.
- W768744188 date "2015-11-01" @default.
- W768744188 modified "2023-10-06" @default.
- W768744188 title "Noradrenaline modulates the presence of gonadotropin-releasing hormone in ovary. The importance of its interrelation on the ovarian steroidogenesis and apoptosis on dioestrus II in rat." @default.
- W768744188 cites W1963550630 @default.
- W768744188 cites W1972174547 @default.
- W768744188 cites W1973309619 @default.
- W768744188 cites W1974032889 @default.
- W768744188 cites W1976947803 @default.
- W768744188 cites W1979699644 @default.
- W768744188 cites W1984172655 @default.
- W768744188 cites W1988079549 @default.
- W768744188 cites W1989431386 @default.
- W768744188 cites W1992152426 @default.
- W768744188 cites W2012977472 @default.
- W768744188 cites W2019179013 @default.
- W768744188 cites W2023084445 @default.
- W768744188 cites W2036603780 @default.
- W768744188 cites W2038483131 @default.
- W768744188 cites W2042104801 @default.
- W768744188 cites W2042570351 @default.
- W768744188 cites W2046244888 @default.
- W768744188 cites W2049909766 @default.
- W768744188 cites W2050915415 @default.
- W768744188 cites W2051526299 @default.
- W768744188 cites W2054172974 @default.
- W768744188 cites W2058401583 @default.
- W768744188 cites W2072031601 @default.
- W768744188 cites W2074090350 @default.
- W768744188 cites W2074595095 @default.
- W768744188 cites W2084158084 @default.
- W768744188 cites W2085031019 @default.
- W768744188 cites W2095378282 @default.
- W768744188 cites W2103453132 @default.
- W768744188 cites W2112112840 @default.
- W768744188 cites W2127139512 @default.
- W768744188 cites W2136949042 @default.
- W768744188 cites W2144940340 @default.
- W768744188 cites W2146264377 @default.
- W768744188 cites W2150203113 @default.
- W768744188 cites W2153576822 @default.
- W768744188 cites W2162810322 @default.
- W768744188 cites W2167413885 @default.
- W768744188 cites W2168583059 @default.
- W768744188 cites W2170026872 @default.
- W768744188 cites W2181657303 @default.
- W768744188 cites W2417053400 @default.
- W768744188 cites W61908197 @default.
- W768744188 doi "https://doi.org/10.1016/j.jsbmb.2015.06.005" @default.
- W768744188 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26144997" @default.
- W768744188 hasPublicationYear "2015" @default.
- W768744188 type Work @default.
- W768744188 sameAs 768744188 @default.
- W768744188 citedByCount "11" @default.
- W768744188 countsByYear W7687441882016 @default.
- W768744188 countsByYear W7687441882017 @default.
- W768744188 countsByYear W7687441882019 @default.
- W768744188 countsByYear W7687441882020 @default.
- W768744188 countsByYear W7687441882021 @default.
- W768744188 countsByYear W7687441882022 @default.
- W768744188 countsByYear W7687441882023 @default.
- W768744188 crossrefType "journal-article" @default.
- W768744188 hasAuthorship W768744188A5051616848 @default.
- W768744188 hasAuthorship W768744188A5059465515 @default.
- W768744188 hasAuthorship W768744188A5059917897 @default.
- W768744188 hasAuthorship W768744188A5068444870 @default.
- W768744188 hasAuthorship W768744188A5073868405 @default.
- W768744188 hasAuthorship W768744188A5087063713 @default.
- W768744188 hasConcept C126322002 @default.
- W768744188 hasConcept C134018914 @default.
- W768744188 hasConcept C190283241 @default.
- W768744188 hasConcept C2778324911 @default.
- W768744188 hasConcept C2778782382 @default.
- W768744188 hasConcept C55493867 @default.
- W768744188 hasConcept C71315377 @default.
- W768744188 hasConcept C71924100 @default.
- W768744188 hasConcept C86803240 @default.
- W768744188 hasConceptScore W768744188C126322002 @default.
- W768744188 hasConceptScore W768744188C134018914 @default.
- W768744188 hasConceptScore W768744188C190283241 @default.
- W768744188 hasConceptScore W768744188C2778324911 @default.
- W768744188 hasConceptScore W768744188C2778782382 @default.
- W768744188 hasConceptScore W768744188C55493867 @default.
- W768744188 hasConceptScore W768744188C71315377 @default.
- W768744188 hasConceptScore W768744188C71924100 @default.
- W768744188 hasConceptScore W768744188C86803240 @default.
- W768744188 hasLocation W7687441881 @default.
- W768744188 hasLocation W7687441882 @default.
- W768744188 hasOpenAccess W768744188 @default.
- W768744188 hasPrimaryLocation W7687441881 @default.
- W768744188 hasRelatedWork W1997759048 @default.