Matches in SemOpenAlex for { <https://semopenalex.org/work/W76875132> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W76875132 endingPage "4" @default.
- W76875132 startingPage "101" @default.
- W76875132 abstract "A RP-HPLC method with rapid sample processing was developed for quantitation of flucloxacillin in human plasma using dicloxacillin as the internal standard. The plasma sample (100 microL) was acidified with glacial acetic acid, and deproteinized by precipitation with acetonitrile. The supernatant was directly injected into the HPLC system. Separation was achieved on an Alltima C18 column (250 mmx4.6 mm I.D., 5 microm), with a mixture of 10 mmol x L(-1) KH2PO4-acetonitrile (64.5:35.5, v/v) as mobile phase. The assay was successfully applied to a randomized, two-period cross-over bioequivalence study in 20 healthy Chinese volunteers following a single oral dose of 250 mg flucloxacillin capsules. A non-compartmental method was used for pharmacokinetic analysis. Compared with data in the literature, flucloxacillin was eliminated more slowly in Chinese than in Caucasians. Cmax, AUC(0-t) and AUC(0-infinity) were tested for bioequivalence after log-transformation of data. No significant difference was found. Tmax was analyzed by Wilcoxon's test and no significant difference was obtained (P > 0.05). Based on these statistical inferences, the two formulations were judged to be bioequivalent and, thus, can be prescribed interchangeably." @default.
- W76875132 created "2016-06-24" @default.
- W76875132 creator A5000650396 @default.
- W76875132 creator A5003088597 @default.
- W76875132 creator A5015921335 @default.
- W76875132 creator A5061642120 @default.
- W76875132 creator A5077762144 @default.
- W76875132 date "2007-02-01" @default.
- W76875132 modified "2023-09-30" @default.
- W76875132 title "RP-HPLC analysis of flucloxacillin in human plasma: validation and application to a bioequivalence study." @default.
- W76875132 cites W1209613245 @default.
- W76875132 cites W1967060898 @default.
- W76875132 cites W1987236807 @default.
- W76875132 cites W2037698344 @default.
- W76875132 cites W2038085907 @default.
- W76875132 cites W2044812683 @default.
- W76875132 cites W2072296799 @default.
- W76875132 cites W2131171455 @default.
- W76875132 cites W2150365003 @default.
- W76875132 cites W2273541760 @default.
- W76875132 cites W2341348044 @default.
- W76875132 cites W2403687069 @default.
- W76875132 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17341027" @default.
- W76875132 hasPublicationYear "2007" @default.
- W76875132 type Work @default.
- W76875132 sameAs 76875132 @default.
- W76875132 citedByCount "8" @default.
- W76875132 countsByYear W768751322012 @default.
- W76875132 countsByYear W768751322014 @default.
- W76875132 countsByYear W768751322017 @default.
- W76875132 countsByYear W768751322018 @default.
- W76875132 countsByYear W768751322020 @default.
- W76875132 crossrefType "journal-article" @default.
- W76875132 hasAuthorship W76875132A5000650396 @default.
- W76875132 hasAuthorship W76875132A5003088597 @default.
- W76875132 hasAuthorship W76875132A5015921335 @default.
- W76875132 hasAuthorship W76875132A5061642120 @default.
- W76875132 hasAuthorship W76875132A5077762144 @default.
- W76875132 hasConcept C112705442 @default.
- W76875132 hasConcept C179998833 @default.
- W76875132 hasConcept C185592680 @default.
- W76875132 hasConcept C22979827 @default.
- W76875132 hasConcept C2778355172 @default.
- W76875132 hasConcept C2779489039 @default.
- W76875132 hasConcept C42404028 @default.
- W76875132 hasConcept C43617362 @default.
- W76875132 hasConcept C523546767 @default.
- W76875132 hasConcept C54355233 @default.
- W76875132 hasConcept C71924100 @default.
- W76875132 hasConcept C74774607 @default.
- W76875132 hasConcept C86803240 @default.
- W76875132 hasConcept C98274493 @default.
- W76875132 hasConceptScore W76875132C112705442 @default.
- W76875132 hasConceptScore W76875132C179998833 @default.
- W76875132 hasConceptScore W76875132C185592680 @default.
- W76875132 hasConceptScore W76875132C22979827 @default.
- W76875132 hasConceptScore W76875132C2778355172 @default.
- W76875132 hasConceptScore W76875132C2779489039 @default.
- W76875132 hasConceptScore W76875132C42404028 @default.
- W76875132 hasConceptScore W76875132C43617362 @default.
- W76875132 hasConceptScore W76875132C523546767 @default.
- W76875132 hasConceptScore W76875132C54355233 @default.
- W76875132 hasConceptScore W76875132C71924100 @default.
- W76875132 hasConceptScore W76875132C74774607 @default.
- W76875132 hasConceptScore W76875132C86803240 @default.
- W76875132 hasConceptScore W76875132C98274493 @default.
- W76875132 hasIssue "2" @default.
- W76875132 hasLocation W768751321 @default.
- W76875132 hasOpenAccess W76875132 @default.
- W76875132 hasPrimaryLocation W768751321 @default.
- W76875132 hasRelatedWork W1522727282 @default.
- W76875132 hasRelatedWork W1866040265 @default.
- W76875132 hasRelatedWork W1968576264 @default.
- W76875132 hasRelatedWork W2004465143 @default.
- W76875132 hasRelatedWork W200962325 @default.
- W76875132 hasRelatedWork W2020529419 @default.
- W76875132 hasRelatedWork W2067877479 @default.
- W76875132 hasRelatedWork W2077341157 @default.
- W76875132 hasRelatedWork W2144254723 @default.
- W76875132 hasRelatedWork W2365585661 @default.
- W76875132 hasRelatedWork W2367096937 @default.
- W76875132 hasRelatedWork W2372740948 @default.
- W76875132 hasRelatedWork W2373202904 @default.
- W76875132 hasRelatedWork W2379434641 @default.
- W76875132 hasRelatedWork W2385389596 @default.
- W76875132 hasRelatedWork W2391610358 @default.
- W76875132 hasRelatedWork W2986044839 @default.
- W76875132 hasRelatedWork W3033562057 @default.
- W76875132 hasRelatedWork W757215554 @default.
- W76875132 hasRelatedWork W2741126116 @default.
- W76875132 hasVolume "62" @default.
- W76875132 isParatext "false" @default.
- W76875132 isRetracted "false" @default.
- W76875132 magId "76875132" @default.
- W76875132 workType "article" @default.