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- W76876094 abstract "This chapter discusses the genetic and environmental influences on tolbutamide metabolism. The use of tolbutamide, which is an oral hypoglycemic sulfonylurea, has decreased since the University Group Diabetes Program (UGDP) reported excessive cardiovascular mortality associated with the administration of the drug. Tolbutamide is metabolized by oxidation of the tolyl methyl group. The initial reaction is mediated by cytochrome P-450 and the product is the benzyl alcohol, hydroxytolbutamide. This step is induced in rats by phenobarbital. Further metabolism to the carboxylic acid occurs via the cytoplasmic enzymes alcohol dehydrogenase and aldehyde dehydrogenase. Humans exhibit a trimodal distribution in the rate of tolbutamide clearance attributed to a single gene affecting the P-450 mediated oxidation. The chapter describes experiments that characterize tolyl methyl oxidation in microsomes from rats pretreated with inducers and from two inbred strains of mice." @default.
- W76876094 created "2016-06-24" @default.
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- W76876094 date "1980-01-01" @default.
- W76876094 modified "2023-09-27" @default.
- W76876094 title "GENETIC AND ENVIRONMENTAL INFLUENCES ON TOLBUTAMIDE METABOLISM" @default.
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- W76876094 doi "https://doi.org/10.1016/b978-0-12-187702-6.50043-8" @default.
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