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- W76898511 abstract "The ultimate objective of this work is to develop potential antidotes for the therapeutic and/or prophylactic treatment of nerve agent intoxication. Particular concern is with soman intoxication where aging of the inhibited enzyme acetylcholinesterase (AChE) is a serious complication factor. Primary emphasis continued to be placed on the investigation of compounds able to inhibit the synthesis of acetylcholine (ACh). A secondary area of interest the investigation of the possibility of combining the ability to slow the rate of aging with the ability to reactivate soman-inhibited AChE. With respect to inhibitors of ACh synthesis, we have continued to investigate the effects of hemicholinium-3 (HC-3), an inhibitor of choline transport and naphthylvinylpyridine hydroxyethyl bromide (B-111), an inhibitor of choline acetyltransferase (CAT), after intracerebroventricular injection in the rat. The ability of HC-3 to prevent the rise in brain ACh levels induced by soman has been confirmed. The ability of B-111 to inhibit brain CAT activity both in soman-treated and untreated rats has been confirmed, although results have been somewhat inconsistent." @default.
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- W76898511 date "1984-01-31" @default.
- W76898511 modified "2023-09-27" @default.
- W76898511 title "Nerve agents. Approaches to treatment/pretreatment. Annual report no. 2, 1 July-31 December 1983" @default.
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