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- W76944165 abstract "The composition of the multisubunit eukaryotic RNA exosome was described more than a decade ago, and structural studies conducted since that time have contributed to our mechanistic understanding of factors that are required for 3'-to-5' RNA processing and decay. This chapter describes the organization of the eukaryotic RNA exosome with a focus on presenting results related to the noncatalytic nine-subunit exosome core as well as the hydrolytic exo- and endoribonuclease Rrp44 (Dis3) and the exoribonuclease Rrp6. This is achieved in large part by describing crystal structures of Rrp44, Rrp6, and the nine-subunit exosome core with an emphasis on how these molecules interact to endow the RNA exosome with its catalytic activities." @default.
- W76944165 created "2016-06-24" @default.
- W76944165 creator A5013774625 @default.
- W76944165 creator A5072097138 @default.
- W76944165 date "2012-01-01" @default.
- W76944165 modified "2023-09-25" @default.
- W76944165 title "Structure and Activities of the Eukaryotic RNA Exosome" @default.
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- W76944165 doi "https://doi.org/10.1016/b978-0-12-404740-2.00003-3" @default.
- W76944165 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5336833" @default.
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