Matches in SemOpenAlex for { <https://semopenalex.org/work/W769492085> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W769492085 abstract "Background: Femoral impaction allografting to reconstitute bone loss during revision hip surgery has shown excellent results. However, limitations with the use of allografts have warranted research to investigate if bone graft substitutes could be a suitable alternative to replace or augment allograft in impaction grafting.;Aims and Methods: The objectives of this thesis were to assess if: The use of hydroxyapatite (HA) in various combinations with allograft will be biologically effective and functionally stable using a cemented impaction grafting technique in an ovine hemiarthroplasty model. The different treatment groups were compared by measuring the ground reaction forces and new bone formation. The addition of mesenchymal stem cells (MSCs) to allograft, HA or an allograft:HA mixture enhances the amount of new bone formation compared with impaction of the scaffold alone in an ovine metaphyseal femoral bone defect model. The architecture of the HA scaffold influences bone formation in an extra-skeletal sheep model.;Results: HA: allograft mixture of up to 90:10 demonstrated similar functional stability and amount of new bone formation as a 50:50 mixture. Addition of MSCs to allograft or a 50:50 allograft:HA mixture enhances the amount of new bone formation compared with unimpacted constructs. HA either alone or combined with MSCs induces bone growth only when constructed in block form and not in identical porous granular form.;Conclusion: HA is a suitable bone substitute to augment allograft and may be replace bone graft completely in impaction grafting of a femoral component. This has important clinical implications as HA is readily available, easy to use in surgery and not associated with the adverse effects encountered with allografts. The use of MSCs in the treatment of osteolysis holds great potential but further work is required to assess if this technology is transferable to humans." @default.
- W769492085 created "2016-06-24" @default.
- W769492085 creator A5001788262 @default.
- W769492085 date "2008-01-01" @default.
- W769492085 modified "2023-09-24" @default.
- W769492085 title "Femoral impaction grafting : using bone graft substitutes" @default.
- W769492085 hasPublicationYear "2008" @default.
- W769492085 type Work @default.
- W769492085 sameAs 769492085 @default.
- W769492085 citedByCount "0" @default.
- W769492085 crossrefType "dissertation" @default.
- W769492085 hasAuthorship W769492085A5001788262 @default.
- W769492085 hasConcept C136229726 @default.
- W769492085 hasConcept C141071460 @default.
- W769492085 hasConcept C142724271 @default.
- W769492085 hasConcept C178790620 @default.
- W769492085 hasConcept C185592680 @default.
- W769492085 hasConcept C198826908 @default.
- W769492085 hasConcept C2775937945 @default.
- W769492085 hasConcept C2776337968 @default.
- W769492085 hasConcept C2780051367 @default.
- W769492085 hasConcept C2911091166 @default.
- W769492085 hasConcept C521977710 @default.
- W769492085 hasConcept C71924100 @default.
- W769492085 hasConcept C89429830 @default.
- W769492085 hasConceptScore W769492085C136229726 @default.
- W769492085 hasConceptScore W769492085C141071460 @default.
- W769492085 hasConceptScore W769492085C142724271 @default.
- W769492085 hasConceptScore W769492085C178790620 @default.
- W769492085 hasConceptScore W769492085C185592680 @default.
- W769492085 hasConceptScore W769492085C198826908 @default.
- W769492085 hasConceptScore W769492085C2775937945 @default.
- W769492085 hasConceptScore W769492085C2776337968 @default.
- W769492085 hasConceptScore W769492085C2780051367 @default.
- W769492085 hasConceptScore W769492085C2911091166 @default.
- W769492085 hasConceptScore W769492085C521977710 @default.
- W769492085 hasConceptScore W769492085C71924100 @default.
- W769492085 hasConceptScore W769492085C89429830 @default.
- W769492085 hasLocation W7694920851 @default.
- W769492085 hasOpenAccess W769492085 @default.
- W769492085 hasPrimaryLocation W7694920851 @default.
- W769492085 hasRelatedWork W120360260 @default.
- W769492085 hasRelatedWork W166739258 @default.
- W769492085 hasRelatedWork W1798934534 @default.
- W769492085 hasRelatedWork W195179784 @default.
- W769492085 hasRelatedWork W1982346698 @default.
- W769492085 hasRelatedWork W1985609394 @default.
- W769492085 hasRelatedWork W2020584712 @default.
- W769492085 hasRelatedWork W2027338818 @default.
- W769492085 hasRelatedWork W2088309095 @default.
- W769492085 hasRelatedWork W2156960174 @default.
- W769492085 hasRelatedWork W2161845595 @default.
- W769492085 hasRelatedWork W2217522711 @default.
- W769492085 hasRelatedWork W2310464067 @default.
- W769492085 hasRelatedWork W2409072469 @default.
- W769492085 hasRelatedWork W2528997213 @default.
- W769492085 hasRelatedWork W2566769430 @default.
- W769492085 hasRelatedWork W2763816611 @default.
- W769492085 hasRelatedWork W2800216180 @default.
- W769492085 hasRelatedWork W2802025179 @default.
- W769492085 hasRelatedWork W3011002263 @default.
- W769492085 isParatext "false" @default.
- W769492085 isRetracted "false" @default.
- W769492085 magId "769492085" @default.
- W769492085 workType "dissertation" @default.