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- W76987000 endingPage "14" @default.
- W76987000 startingPage "805" @default.
- W76987000 abstract "Severe or chronic disease can lead to cachexia which involves weight loss and muscle wasting. Cancer cachexia contributes significantly to disease morbidity and mortality. Multiple studies have shown that the metabolic changes that occur with cancer cachexia are unique compared to that of starvation. Specifically, cancer patients seem to lose a larger proportion of skeletal muscle mass. There are three pathways that contribute to muscle protein degradation: the lysosomal system, cytosolic proteases and the ubiquitin (Ub)-proteasome pathway. The Ub-proteasome pathway seems to account for the majority of skeletal muscle degradation in cancer cachexia and is stimulated by several cytokines including tumor necrosis factor-alpha, interleukin-1beta, interleukin-6, interferon-gamma and proteolysis-inducing factor. Cachexia is particularly severe in pancreatic cancer and contributes significantly to the quality of life and mortality of these patients. Several factors contribute to weight loss in these patients, including alimentary obstruction, pain, depression, side effects of therapy and a high catabolic state. Although no single agent has proven to halt cachexia in these patients there has been some progress in the areas of nutrition with supplementation and pharmacological agents such as megesterol acetate, steroids and experimental trials targeting cytokines that stimulate the Ub-proteasome pathway." @default.
- W76987000 created "2016-06-24" @default.
- W76987000 creator A5023596709 @default.
- W76987000 creator A5025468423 @default.
- W76987000 creator A5038117732 @default.
- W76987000 creator A5038833289 @default.
- W76987000 date "2007-07-01" @default.
- W76987000 modified "2023-10-02" @default.
- W76987000 title "Mechanisms of skeletal muscle degradation and its therapy in cancer cachexia." @default.
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