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- W769937701 abstract "The characterization, ontogeny and regulation of the murine myocardial muscarinic receptor were examined by equilibrium ligand binding techniques using the agonist ligand, [ Hjcis-methyldioxolane (L^HjCD). Binding of [^HJCD was specific and of high affinity, to a single site in the nanomolar range (K,=6.7nM) with Bm= =5.6 Q ITlaX fmol/mg tissue. Competitive inhibition studies gave Hill slopes < 1. o Developmental studies showed that [ H]CD binding was present in the mouse fetal heart. Adult levels of binding were reached by the time of birth. A significant peak in binding was seen between days 16-20 neonatal. Changes were due to alterations in receptor density. GppNHp-induced reductions in agonist binding were present at all ages and in all regions of the murine heart. Receptor density measured by agonist or antagonist binding was greater in atria than in ventricles. In addition to GppNHp, fluoride also regulated muscarinic agonist receptor binding." @default.
- W769937701 created "2016-06-24" @default.
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- W769937701 date "1982-01-01" @default.
- W769937701 modified "2023-09-27" @default.
- W769937701 title "THE DEVELOPMENT AND REGULATION OF THE MURINE MYOCARDIAL MUSCARINIC RECEPTOR." @default.
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