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- W770002130 abstract "Benign prostatic hyperplasia (BPH) starts the development in animals aging about 1 – 2 years. 80% of 5 years-old dogs have histologic evidences of BPH. Despite the little knowledge concerning about this disease, dihydrotestosterone is the main involved hormone. Recently, the effect of botulinum toxin A (BT-A) on rat and human prostate was investigated, and prostatic parenchyma atrophy and decrease in glandular volume were observed. The dog is one of a few animals that can develop BPH spontaneously and is frequently used as an animal model for human prostatic hyperplasia. Based on that, this study aimed to provide information on BT-A effects on prostate, libido and semen quality, in comparison to orchiectomized dogs. For that, 18 adults dogs, with Ultrasonographic evidences of BPH were submitted to orchiectomy or administration of 250 or 500 U of BT-A, and evaluated along 16 weeks. Orchiectomy presented excellent results on BPH, reducing the prostate volume up to 80%. Administration of BT-A did not significantly interfered on libido, erection or semen characteristics. Local and systemic effects also were not observed. Administration of 250 U of BT-A has promoved a maximum decrease of 9,4% on prostatic volume. However, this reduction was not statistically significant. On the other hand, 500 U of BTA administration has shown to significantly reduce the length, height and volume of prostate. This way, the present study is an innovative and singular contribution for the knowledge of the effects of BT-A on canine prostate. KEY-WORDS: Benign Prostatic Hyperplasia, Botulinum Toxin A, Dog, Orchiectomy, Prostate, Semen." @default.
- W770002130 created "2016-06-24" @default.
- W770002130 creator A5061056811 @default.
- W770002130 date "2008-02-22" @default.
- W770002130 modified "2023-09-24" @default.
- W770002130 title "ESTUDO COMPARATIVO ENTRE A ADMINISTRAÇÃO DE TOXINA BOTULÍNICA A E A ORQUIECTOMIA NO TRATAMENTO DA HIPERPLASIA PROSTÁTICA BENIGNA DO CÃO." @default.
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