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- W770348658 abstract "在酶催化反应中,不仅存在底物诱导的酶构象变化,也存在酶诱导的底物构象变化,以达到二者最佳的结合,这称为“诱导吻合”(“induced fit”).Meadows等用2′-,3′-和5′-CMP为抑制剂,通过NMR研究了它们在和RNase A结合时碱基相对于核糖的取向,他们的结论是,2′-CMP采取syn构象,3′-和5′-CMP采取anti构象,2′-CMP和3′-CMP(5′-CMP)取向的不同,和磷酸结合的位置有关系,但作为RNase A的底物的C>P(或U>P),它们在和RNaseA结合时以何种构象为有利构象的问题还没有得到直接的说明." @default.
- W770348658 created "2016-06-24" @default.
- W770348658 creator A5027011962 @default.
- W770348658 date "1994-02-15" @default.
- W770348658 modified "2023-09-24" @default.
- W770348658 title "构象固定的U〉P衍生物的合成及其RNase A底物性质" @default.
- W770348658 hasPublicationYear "1994" @default.
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