Matches in SemOpenAlex for { <https://semopenalex.org/work/W77077204> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W77077204 abstract "Although both the SHARP and the Asian-Pacific trials showed improved overall survival (OS) for sorafenib, the magnitude of benefit was substantially less for Asians, who have a higher prevalence of hepatitis B viral (HBV) infection. Whether the worse prognosis is related to ethnicity or to the etiology of hepatocellular carcinoma (HCC) remains unclear. The aim of this study was to identify prognostic factors among patients with HCC who received sorafenib in British Columbia (BC), which has a sizeable Asian population.A total of 255 consecutive patients with advanced HCC who initiated sorafenib from January 2008 to February 2013 were identified using our pharmacy database. Clinicopathological variables and outcomes were retrospectively collected. Prognostic factors were assessed by univariate and multivariate analyses.Median age was 63 years, 80.2% were men, and 38% were Asian. Among them, 34.5% had HBV and 29.8% had hepatitis C viral (HCV) infection. In addition, 68.6% had cirrhosis and 45.9% had liver-limited disease. Median progression-free and OS were 3.7 [95% confidence interval (CI): 3.3-4.2] and 7.5 months (95% CI: 5.7-9.2), respectively. On multivariate analysis, Eastern Cooperative Oncology Group performance status (ECOG PS) and HCV positivity correlated with better OS (P<0.001 and 0.04, respectively), but ethnicity did not (P=0.622).When treated with sorafenib at the same institution, Asians and Caucasians with advanced HCC had similar OS. ECOG PS and HCV were the only significant prognostic factors. A higher proportion of HCV positivity might explain why the SHARP trial achieved better OS when compared to the Asian-Pacific trial." @default.
- W77077204 created "2016-06-24" @default.
- W77077204 creator A5001731680 @default.
- W77077204 creator A5039850848 @default.
- W77077204 creator A5070331492 @default.
- W77077204 creator A5075109756 @default.
- W77077204 creator A5089913686 @default.
- W77077204 date "2014-08-01" @default.
- W77077204 modified "2023-10-03" @default.
- W77077204 title "Relationship of ethnicity and overall survival in patients treated with sorafenib for advanced hepatocellular carcinoma." @default.
- W77077204 cites W1604740730 @default.
- W77077204 cites W1971837077 @default.
- W77077204 cites W1976048849 @default.
- W77077204 cites W1994193851 @default.
- W77077204 cites W1998832059 @default.
- W77077204 cites W2002800484 @default.
- W77077204 cites W2020830322 @default.
- W77077204 cites W2058887247 @default.
- W77077204 cites W2070996506 @default.
- W77077204 cites W2106787323 @default.
- W77077204 cites W2137813001 @default.
- W77077204 cites W2140765540 @default.
- W77077204 cites W2170566133 @default.
- W77077204 cites W2213448039 @default.
- W77077204 cites W3139763557 @default.
- W77077204 doi "https://doi.org/10.3978/j.issn.2078-6891.2014.036" @default.
- W77077204 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4110502" @default.
- W77077204 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25083298" @default.
- W77077204 hasPublicationYear "2014" @default.
- W77077204 type Work @default.
- W77077204 sameAs 77077204 @default.
- W77077204 citedByCount "9" @default.
- W77077204 countsByYear W770772042015 @default.
- W77077204 countsByYear W770772042016 @default.
- W77077204 countsByYear W770772042018 @default.
- W77077204 countsByYear W770772042019 @default.
- W77077204 countsByYear W770772042020 @default.
- W77077204 countsByYear W770772042023 @default.
- W77077204 crossrefType "journal-article" @default.
- W77077204 hasAuthorship W77077204A5001731680 @default.
- W77077204 hasAuthorship W77077204A5039850848 @default.
- W77077204 hasAuthorship W77077204A5070331492 @default.
- W77077204 hasAuthorship W77077204A5075109756 @default.
- W77077204 hasAuthorship W77077204A5089913686 @default.
- W77077204 hasConcept C126322002 @default.
- W77077204 hasConcept C143998085 @default.
- W77077204 hasConcept C144301174 @default.
- W77077204 hasConcept C207103383 @default.
- W77077204 hasConcept C2776455275 @default.
- W77077204 hasConcept C2777072776 @default.
- W77077204 hasConcept C2777214474 @default.
- W77077204 hasConcept C2777382497 @default.
- W77077204 hasConcept C2778019345 @default.
- W77077204 hasConcept C2778695046 @default.
- W77077204 hasConcept C2908647359 @default.
- W77077204 hasConcept C38180746 @default.
- W77077204 hasConcept C44249647 @default.
- W77077204 hasConcept C71924100 @default.
- W77077204 hasConcept C90924648 @default.
- W77077204 hasConcept C99454951 @default.
- W77077204 hasConceptScore W77077204C126322002 @default.
- W77077204 hasConceptScore W77077204C143998085 @default.
- W77077204 hasConceptScore W77077204C144301174 @default.
- W77077204 hasConceptScore W77077204C207103383 @default.
- W77077204 hasConceptScore W77077204C2776455275 @default.
- W77077204 hasConceptScore W77077204C2777072776 @default.
- W77077204 hasConceptScore W77077204C2777214474 @default.
- W77077204 hasConceptScore W77077204C2777382497 @default.
- W77077204 hasConceptScore W77077204C2778019345 @default.
- W77077204 hasConceptScore W77077204C2778695046 @default.
- W77077204 hasConceptScore W77077204C2908647359 @default.
- W77077204 hasConceptScore W77077204C38180746 @default.
- W77077204 hasConceptScore W77077204C44249647 @default.
- W77077204 hasConceptScore W77077204C71924100 @default.
- W77077204 hasConceptScore W77077204C90924648 @default.
- W77077204 hasConceptScore W77077204C99454951 @default.
- W77077204 hasLocation W770772041 @default.
- W77077204 hasOpenAccess W77077204 @default.
- W77077204 hasPrimaryLocation W770772041 @default.
- W77077204 hasRelatedWork W1971837077 @default.
- W77077204 hasRelatedWork W1994193851 @default.
- W77077204 isParatext "false" @default.
- W77077204 isRetracted "false" @default.
- W77077204 magId "77077204" @default.
- W77077204 workType "article" @default.